Evidence is presented of universal behavior in modulationally unstable media. An ensemble of nonlinear evolution equations, including three partial differential equations, an integro-differential equation, a nonlocal system and a differential-difference equation, is studied analytically and numerically. Collectively, these systems arise in a variety of applications in the physical and mathematical sciences, including water waves, optics, acoustics, Bose-Einstein condensation, and more. All these models exhibit modulational instability, namely, the property that a constant background is unstable to long-wavelength perturbations. In this work, each of these systems is studied analytically and numerically for a number of different initial perturbations of the constant background, and it is shown that, for all systems and for all initial conditions considered, the dynamics gives rise to a remarkably similar structure comprised of two outer, quiescent sectors separated by a wedge-shaped central region characterized by modulated periodic oscillations. A heuristic criterion that allows one to compute some of the properties of the central oscillation region is also given.AMS subject classifications. 35Q55, 37Kxx, 37K40, 74J30 Remarkably, the nonlinear stage of MI in the NLS equation with periodic boundary conditions is described in terms of a homoclinic structure [8,50] characterized by two qualitatively different families of recurrent (or, more strictly, doubly-periodic) solutions, through which the perturbation is cyclically amplified and back-converted to the background. These two families are separated by the so called Akhmediev breather, which represents the separatrix of the homoclinic structure, featuring a single cycle of conversion and back-conversion, with its unstable manifold corresponding to the MI linearized growth.In the more general non-periodic case (i.e., for localized perturbations of the constant background), however, the dynamics of MI is strikingly different. Indeed, using the IST for the focusing NLS equation with non-zero background [13], it was shown in [12] that in this scenario (i.e., constant boundary conditions at infinity, corresponding to localized per- †