Blood flow through arterial circulation can be characterized by fluid transport in flexible tubes and modeled mathematically using the conservation of mass and momentum. A one-dimensional model for two-layer blood flow with different blood velocities and the same constant density in each layer derived from the Euler equations of gas dynamics by taking the vertical average across each layer. This work presents interactions of elementary waves with a weak discontinuity for the quasilinear 3 × 3 system of conservation laws governing the two-layer blood flow in arteries. Exploiting elementary waves as a single-parameter curve, we study the Riemann solution uniquely and consequently establish the condition on initial data for the existence of a solution to the Riemann problem. Furthermore, we discuss the evolution of weak discontinuity waves and subsequently derive their amplitudes; in what follows, we investigate the interactions of weak discontinuity with contact discontinuity and shocks. Finally, a series of numerical tests have been performed to understand the impact of shock strength and the initial data on the amplitudes of reflected and transmitted waves and the jumps in shock acceleration.