This review article presents various multi-DOF application systems that utilize smart magnetorheological (MR) fluid. It is well known that MR fluid has been actively studied and applied in many practical systems such as vehicle suspension dampers. The design requirements for the effective applications of MR fluid include geometry optimization, working principles, and control schemes. The geometry optimization is mostly related to the size minimization with high damping force, while the working principles are classified into the shear mode, the flow mode, and the squeeze mode depending on the dominant dynamic motion of the application system. The control schemes are crucial to achieve final targets such as robust vibration control against disturbances. It should be addressed that advanced output performances of MR application systems heavily depends on these three requirements. This review article presents numerous application systems such as sandwich structures, dampers, mounts, brakes, and clutches, which have been developed considering the three design requirements. In addition, in this article some merits and demerits of each application system are discussed to enable potential researchers to develop more effective and practical MR application systems featuring the multi-DOF dynamic motions.