A fourth-order B-spline collocation method has been applied for numerical study of Burgers-Fisher equation, which illustrates many situations occurring in various fields of science and engineering including nonlinear optics, gas dynamics, chemical physics, heat conduction, and so on. The present method is successfully applied to solve the Burgers-Fisher equation taking into consideration various parametric values. The scheme is found to be convergent. Crank-Nicolson scheme has been employed for the discretization. Quasi-linearization technique has been employed to deal with the nonlinearity of equations. The stability of the method has been discussed using Fourier series analysis (von Neumann method), and it has been observed that the method is unconditionally stable. In order to demonstrate the effectiveness of the scheme, numerical experiments have been performed on various examples. The solutions obtained are compared with results available in the literature, which shows that the proposed scheme is satisfactorily accurate and suitable for solving such problems with minimal computational efforts.