Wave propagation in microtubule-based bio-nano-architected networks: A lesson from nature

Jafari, Hamid; Yazdi, Mohammad Reza Hairi; Fakhrabadi, Mir Masoud Seyyed

doi:10.1016/j.ijmecsci.2019.105175

Cited by 18 publications

(9 citation statements)

References 43 publications

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“…Such mode of mechanical communication has been studied for more than a decade now; ,, however, the focus has been mainly centered on relatively static or quasi-static forces. ,− In this paper, we explore the plausibility and efficacy of dynamic mechanical communication mediated by traveling wave packets along random elastic fibrous networks reflecting the ECM that surrounds living cells. Indeed, the dispersion and relaxation of elastic waves in fibrous materials has been studied, − however, not in the context of cell-to-cell communication through the ECM. Our simulations indicate that dynamic mechanical perturbations exerted by cell contractile forces may provide a potential mechanism of vibrational communication between cells.…”

Section: Discussionmentioning

confidence: 99%

Does the Extracellular Matrix Support Cell–Cell Communication by Elastic Wave Packets?

Panchenko

Tchaicheeyan

Berinskii

et al. 2022

ACS Biomater. Sci. Eng.

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The extracellular matrix (ECM) is a fibrous network supporting biological cells and provides them a medium for interaction. Cells modify the ECM by applying traction forces, and these forces can propagate to long ranges and establish a mechanism of mechanical communication between neighboring cells. Previous studies have mainly focused on analysis of static force transmission across the ECM. In this study, we explore the plausibility of dynamic mechanical interaction, expressed as vibrations or abrupt fluctuations, giving rise to elastic waves propagating along ECM fibers. We use a numerical mass-spring model to simulate the longitudinal and transversal waves propagating along a single ECM fiber and across a 2D random fiber network. The elastic waves are induced by an active contracting cell (signaler) and received by a passive neighboring cell (receiver). We show that dynamic wave propagation may amplify the signal at the receiver end and support up to an order of magnitude stronger mechanical cues and longer-ranged communication relative to static transmission. Also, we report an optimal impulse duration corresponding to the most effective transmission, as well as extreme fast impulses, in which the waves are encaged around the active cell and do not reach the neighboring cell, possibly due to the Anderson localization effect. Finally, we also demonstrate that extracellular fluid viscosity reduces, but still allows, dynamic propagation along embedded ECM fibers. Our results motivate future biological experiments in mechanobiology to investigate, on the one hand, the mechanosensitivity of cells to dynamic forces traveling and guided by the ECM and, on the other hand, the impact of ECM architecture and remodeling on dynamic force transmission and its spectral filtering, dispersion, and decay.

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Section: Discussionmentioning

confidence: 99%

Does the Extracellular Matrix Support Cell–Cell Communication by Elastic Wave Packets?

Panchenko

Tchaicheeyan

Berinskii

et al. 2022

ACS Biomater. Sci. Eng.

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“…In addition to the design methods mentioned above, it is worth noting recently that many studies have begun to combine biology with mechanics, taking inspiration from biological systems to create new knots [24][25][26][27][28]. These new structural metamaterials have superior mechanical properties, better designability and tunability, and are new ideas for future structural design of acoustic metamaterials.…”

Section: Bioinspired Acoustic Metamaterialsmentioning

confidence: 99%

“…It plays an important role in the processes of division, intercellular transport, and internal organization of cellular components. Jafari et al [27] investigated the propagation of elastic waves in periodic networks of various 2D microtubule bionanostructures, and analyzed their dynamic properties, providing the possibility for further applications. Figure 6 depicts a single microtubule and the method by which it builds its architectural structure.…”

Section: Bioinspired Acoustic Metamaterialsmentioning

confidence: 99%

“…It is worth noting that metamaterials that combine mechanics and biology have emerged in recent years and have begun to attract the attention of researchers [24,25], such as DNA-inspired chiral metamaterials [26], microtubules composed of Biological nanonetworks [27], layered cellular materials [28]. These biological systems-inspired materials offer a completely new approach to the structural design of acoustic metamaterials.…”

Section: Introductionmentioning

confidence: 99%

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Review and prospects of metamaterials used to control elastic waves and vibrations

Dai

Zhang²,

Zheng³

et al. 2022

Front. Phys.

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Acoustic metamaterials, artificial composite structures with exotic material properties used to control elastic waves, have become a new frontier in physics, materials science, engineering and chemistry. In this paper, the research progress and development prospect of acoustic metamaterials are reviewed. Related studies on passive acoustic metamaterials and active acoustic metamaterials are introduced and compared. Additionally, we discuss approaches to material structure design, including topology optimization approaches, as well as bio-inspired and fractal geometry-based approaches to structure design. Finally, we summarize and look forward to the prospects and directions of acoustic metamaterial research. With the development of additive manufacturing technology, the research potential of acoustic metamaterials is huge.

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“…Application of the bio-materials as alternatives for the currently used precursors of the 3D printers and metamaterials can open new promising horizons in the implementation of biocompatible devices such as internal parts of the artificial organs. Experimental [19] and computational [48,49] studies essentially proved the possibility of making regular networks out of the MTs, and their small networks were realized and analyzed before [19]. Therefore, one can imagine the design and fabrication of the architected MTbased bio-nanometamaterials with possible applications in next-generation biocompatible devices.…”

Section: Introductionmentioning

confidence: 99%

Orientation-dependent mechanical properties of planar microtubule-based bio-nanometamaterials

Jafari¹,

Sepehri²,

Yazdi³

et al. 2020

Phys. Scr.

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Microtubules are protein-based filaments that carry out essential biological roles of eukaryotic cells. They play, in vivo, critical roles in a wide variety of physical situations such as maintaining cell shape, supporting cellular motions, and playing significant roles in both intracellular transport and cellular division. To perform some of these functions, microtubules may need to form different topologies in various orientations. Therefore, the need to introduce different structures of microtubules arises. Orientation-dependent architected structures are a type of periodic architected materials that can exhibit various mechanical properties in different orientations. In the present study, several periodic architectures of various topologies are investigated numerically, and their mechanical properties (elastic modulus, Poisson’s ratio, and natural frequencies) are analyzed in different spatial orientations. For this purpose, the representative volume elements are constructed by considering unit cells of different models aligned in different spatial angles, and their elastic moduli and Poisson’s ratios are obtained by the finite element method. Then the finite element equation of motion for the given structures are solved to find their six natural frequencies. Besides, Bloch’s theorem is implemented to study wave propagation and compare the bandgap widths of the structures in different orientations. It is found that while the elastic properties of some architected structures may increase as the orientation angle increases from zero, for some others, a reduction in the elastic moduli can be observed as the angle rises. Further, it is seen that some structures may exhibit positive (and high) values of Poisson’s ratio in some angles, while for a different orientation, these values turn out to be negative. Also, the effects of orientation angle on the natural frequencies and stop-band performance are observed to be significant in some topologies and negligible in some others. A better understanding of the behavior of architected structures in different orientations may provide new ways to design and manufacture various structures with enhanced and tunable mechanical properties.

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Wave propagation in microtubule-based bio-nano-architected networks: A lesson from nature

Cited by 18 publications

References 43 publications

Does the Extracellular Matrix Support Cell–Cell Communication by Elastic Wave Packets?

Does the Extracellular Matrix Support Cell–Cell Communication by Elastic Wave Packets?

Review and prospects of metamaterials used to control elastic waves and vibrations

Orientation-dependent mechanical properties of planar microtubule-based bio-nanometamaterials

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