Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk

Adrián, Javier; Pasche, Stéphanie; Diserens, Jean-Marc; Sánchez‐Baeza, Francisco; Gao, Hui; Marco, M.‐Pilar; Voirin, Guy

doi:10.1016/j.bios.2009.04.036

Cited by 58 publications

(33 citation statements)

References 37 publications

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“…The measured LOD of 1x10 -5 is therefore conservatively estimated to correspond to limit of detection for bound proteins of 5 pg/mm 2 (or volume mass concentration of 0.08 μg/ml). This limit of detection is comparable to that of other optimized optical devices [6,7]. Figure 10.…”

Section: Point-of-care Diagnostics Of Infectious Diseasessupporting

confidence: 66%

“…Two separate regions of the sensor (each approximately 5 mm long) were functionalized with different receptors by using a silicon spacer with two distinct cut-out regions. More complex patterns can be realized using custom microfluidic devices with independent channels to flow the receptor to be surface immobilized ahead of the sensing experiment [6] or, as more scalable approach, using protein spotting ahead of the fluidic cartridge assembly [7].…”

Section: Multiplexed Sensor Operationmentioning

confidence: 99%

“…To achieve detection of very low concentration of small mass analytes a combination competitive and amplification assay has been reported [7].…”

Section: Point-of-care Diagnostics Of Infectious Diseasesmentioning

confidence: 99%

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Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases

2011

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The TWIST platform is an optical evanescent wave sensor which enables a label-free immunoassay-based portable instrument. The approach is based on input grating coupler sensors serving as functionalized sensing devices. Binding of the target analyte to the receptor-coated grating is detected by wavelength interrogation in the telecom spectral range. We have demonstrated that high performance volumetric sensing can be achieved using a compact, low-cost telecom laser as light source. The system footprint including light source, detectors and digitizers is compact. The platform is amenable to multiplexed operation. We demonstrated a two-output system which enables detection of an analyte with an on-chip reference signal.

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Section: Point-of-care Diagnostics Of Infectious Diseasessupporting

confidence: 66%

Section: Multiplexed Sensor Operationmentioning

confidence: 99%

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Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases

2011

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“…Because of the fact that they can carry harmful bacteria and microorganisms, they can spoil the products and make people sick. For this reason, many researchers have attempted to develop biosensors for detecting compositions and some contaminants such as enterotoxins, antibiotics, bacteria, aflatoxins [5,6,7,8,9] and monitoring some critical parameters such as the cutting time, pH, temperature, and enzyme concentration [10,11,12,13,14,15,16] in milk and its products.…”

Section: Introductionmentioning

confidence: 99%

Bent Fiber Sensor for Preservative Detection in Milk

Saracoglu

Hayber

2016

Sensors

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A fiber optic sensor sensitive to refractive index changes of the outer region of the fiber cladding is presented. The sensor uses bent plastic optical fibers in different bending lengths to increase sensitivity. Measurements were made for low-fat milk, the refractive index of which is altered by some preservatives such as formaldehyde, hydrogen peroxide, and sodium carbonate. Concentrations of the preservatives in the milk were changed between 0% and 14.3% while the refractive indices occurred between 1.34550 and 1.35093 for the minimum (0%) and maximum (14.286%) concentrations of sodium carbonate, respectively. Due to bending-induced sensitivity, the sensor is able to detect refractive index changes less of than 0.4%. The results show that there is excellent linearity between the concentration and normalized response of the sensor.

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“…Owing to the complex environmental matrix, one reason for FQs residues is the lack of reliable and effective analytical methods. A variety of analytical methods have been reported for the analysis of the FQs including HPLC-MS, HPLC-UV, HPLC-FLD [19][20][21][22][23][24], flow injection chemiluminescence [25,26], RRS [27], localized surface plasmon resonance (LSPR) [28], spectrophotometry [29], fluorimetry [30,31], electrochemistry [32,33], immunoassays [34,35] and luminescence [36], etc.…”

Section: Introductionmentioning

confidence: 99%

The dynamics of a novel method coupling high‐performance liquid chromatography with resonance Rayleigh scattering

Zhang

Peng

Liu

et al. 2011

J of Separation Science

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The dynamics of a novel method coupling high-performance liquid chromatography (HPLC) with resonance Rayleigh scattering (RRS) is presented in the paper. The method was employed in the detection of fluoroquinolones (FQs) of urine samples from healthy human beings, by forming ion-association complexes between the components separated from HPLC and [Ce(OH)(3) ](+) as the molecular recognition probe. The RRS signal was measured at λ(ex) =λ(em) =365 nm. It was applied to detect three FQs and obtained satisfactory results. The RRS spectral characteristics of the analytes and the kinetics of flow rate, proportion of organic phase, reaction time and the aggregation level of ion-association complexes were investigated, which provided a new basis for the development of the hyphenated techniques. It was established that the presence of HPLC-RRS would open up a new field in the determination of analytes in the absence of UV or fluorescence.

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Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk

Cited by 58 publications

References 37 publications

Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases

Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases

Bent Fiber Sensor for Preservative Detection in Milk

The dynamics of a novel method coupling high‐performance liquid chromatography with resonance Rayleigh scattering

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