Wavelength Discrimination in Drosophila Suggests a Role of Rhodopsin 1 in Color Vision

Garbers, Christian; Wachtler, Thomas

doi:10.1371/journal.pone.0155728

Cited by 10 publications

(8 citation statements)

References 46 publications

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“…Functional imaging revealed no evidence for the integration of R1-R6 signals at the level of R7/R8 terminal responses (Schnaitmann et al 2018). However, a contribution of R1-R6 and of their downstream neurons L1 and L2 to color discrimination has been demonstrated in a behavioral study (Schnaitmann et al 2013;Garbers and Wachtler 2016). Therefore, the signals of R1-R6 must be integrated into the Drosophila color vision circuitry downstream of R7/ R8 terminals.…”

Section: Circuit Mechanisms Underlying Color Visionmentioning

confidence: 94%

“…Based on their broad-band sensitivity and major role in motion vision (Heisenberg and Buchner 1977;Yamaguchi et al 2008;Wardill et al 2012), R1-R6 were thought not to contribute to fly color vision (Troje 1993). This view was challenged by the finding that Drosophila color discrimination is described best using a receptor noise-limited model that incorporates R1-R6 (Hernández de Salomon and Spatz 1983;Schnaitmann et al 2013;Garbers and Wachtler 2016). Most importantly, flies with R1-R6 and R7y as only functional photoreceptors are able to discriminate blue and green (Schnaitmann et al 2013).…”

Section: Photoreceptor Contributions To Color Visionmentioning

confidence: 99%

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Color vision in insects: insights from Drosophila

2020

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Color vision is an important sensory capability that enhances the detection of contrast in retinal images. Monochromatic animals exclusively detect temporal and spatial changes in luminance, whereas two or more types of photoreceptors and neuronal circuitries for the comparison of their responses enable animals to differentiate spectral information independent of intensity. Much of what we know about the cellular and physiological mechanisms underlying color vision comes from research on vertebrates including primates. In insects, many important discoveries have been made, but direct insights into the physiology and circuit implementation of color vision are still limited. Recent advances in Drosophila systems neuroscience suggest that a complete insect color vision circuitry, from photoreceptors to behavior, including all elements and computations, can be revealed in future. Here, we review fundamental concepts in color vision alongside our current understanding of the neuronal basis of color vision in Drosophila, including side views to selected other insects.

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Section: Circuit Mechanisms Underlying Color Visionmentioning

confidence: 94%

Section: Photoreceptor Contributions To Color Visionmentioning

confidence: 99%

Color vision in insects: insights from Drosophila

2020

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“…Drosophila have little perception of red-shifted light because they lack the corresponding photoreceptors (Garbers and Wachtler, 2016), so it is not surprising that they could not perceive the dark objects in this context. In addition to showing an absence of object perception in this context, these experiments indicate that the choice profiles revealed earlier are not an artifact of the maze geometry; only visible objects revealed a significant choice profile.…”

Section: Repulsion and Attraction For Different Sized Objects Remain mentioning

confidence: 99%

Innate visual preferences and behavioral flexibility inDrosophila

Grabowska

Steeves

Alpay

et al. 2018

Journal of Experimental Biology

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Visual decision making in animals is influenced by innate preferences as well as experience. Interaction between hard-wired responses and changing motivational states determines whether a visual stimulus is attractive, aversive or neutral. It is, however, difficult to separate the relative contribution of nature versus nurture in experimental paradigms, especially for more complex visual parameters such as the shape of objects. We used a closed-loop virtual reality paradigm for walking Drosophila to uncover innate visual preferences for the shape and size of objects, in a recursive choice scenario allowing the flies to reveal their visual preferences over time. We found that Drosophila melanogaster display a robust attraction/repulsion profile for a range of object sizes in this paradigm, and that this visual preference profile remains evident under a variety of conditions and persists into old age. We also demonstrate a level of flexibility in this behavior: innate repulsion to certain objects could be transiently overridden if these were novel, although this effect was only evident in younger flies. Finally, we show that a neuromodulatory circuit in the fly brain, Drosophila neuropeptide F (dNPF), can be recruited to guide visual decision making. Optogenetic activation of dNPF-expressing neurons converted a visually repulsive object into a more attractive object. This suggests that dNPF activity in the Drosophila brain guides ongoing visual choices, to override innate preferences and thereby provide a necessary level of behavioral flexibility in visual decision making.

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“…Much of what is understood about animal colour vision is derived from studies of vertebrates and only more recently have investigations revealed the neural basis of colour information processing in insects. Colour information processing in Drosophila has been investigated using behavioural experiments 10,11 , modelling 12 and by visualising neural responses directly in the fly brain, in response to light stimulation with genetic manipulation 1,2 . Colour opponency begins at the first visual synapse, the photoreceptor terminal, with reciprocal inhibition occurring between paired R7 and R8 receptors 1 .…”

Section: Introductionmentioning

confidence: 99%

The spectral sensitivity ofDrosophilaphotoreceptors

Sharkey

Blanco

Leibowitz

et al. 2020

Preprint

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14Drosophila melanogaster has long been a popular model insect species, due in large part to 15 the availability of genetic tools and is fast becoming the model for insect colour vision. Key 16 to understanding colour reception in Drosophila is in-depth knowledge of spectral inputs 17 and downstream neural processing. While recent studies have sparked renewed interest in 18 colour processing in Drosophila, photoreceptor spectral sensitivity measurements have yet 19 to be carried out in vivo. We have fully characterised the spectral input to the motion and 20 colour vision pathways, and directly measured the effects of spectral modulating factors, 21 screening pigment density and carotenoid-based ocular pigments. All receptor sensitivities 22 had significant shifts in spectral sensitivity compared to previous measurements. Notably, 23 the spectral range of the Rh6 visual pigment is substantially broadened and its peak 24 sensitivity is shifted by 92 nm from 508 to 600 nm. We propose that this deviation can be 25 explained by transmission of long wavelengths through the red screening pigment and by 26 the presence of the blue-absorbing filter in the R7y receptors. Further, we tested direct 27 interactions between photoreceptors and found evidence of interactions between inner and 28 outer receptors, in agreement with previous findings of cross-modulation between receptor 29 outputs in the lamina. 30

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Wavelength Discrimination in Drosophila Suggests a Role of Rhodopsin 1 in Color Vision

Cited by 10 publications

References 46 publications

Color vision in insects: insights from Drosophila

Color vision in insects: insights from Drosophila

Innate visual preferences and behavioral flexibility inDrosophila

The spectral sensitivity ofDrosophilaphotoreceptors

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