Wavelength-interrogated optical sensor for biochemical applications

Abstract

A novel miniature integrated-optical sensor for versatile multichannel applications is described. Wavelength-modulation techniques using laser diodes (vertical-cavity surface-emitting lasers) are used to interrogate multiple-waveguide sensing regions on a single integrated-optical chip for accurate measurement of effective refractive-index changes at a high data rate. With the experimental miniature sensor system, a resolution of DN(PP) = 10(-7) (short term, peak to peak) of the effective refractive index was demonstrated. In terms of surface-mass coverage, this resolution corresponds to D?(PP) = 130 fg/mm(2).

Nanoimprint Lithography with UV‐Curable Hyperbranched Polymer Nanocomposites

“…Nano-scale patterns are used in an increasing number of applications, ranging from optical sensors [1,2] to transistors. [3] Nanoimprint lithography (NIL) was first reported by Chou [4,5] and is nowadays a well established contact lithography technique that allows for low-cost and high throughput production of nano-patterns and devices with sub-10 nm [6] resolution.…”

Size-selective analyte detection in an integrated optical Young interferometer biosensor

“…Applying this method, an LOD of 3 x 10 -6 RIU is reported. Besides, a so-called wavelength interrogated optical sensor (WIOS) based on grating couplers has been developed [19,20]. One grating coupler is used for coupling the light into a singlemode waveguide.…”

“…Assuming that the specific bound particles is a virus, the RI of the analyte is analyte n =1.41 [20] …”

Integrated optical sensor utilizing slow-light propagation in grated-waveguide cavities

“…[19,21,32,[80][81][82][83]. In addition to these two modes we will consider in this thesis also mechano-optical sensing.…”

“…In recent years monolithically integrated optical resonant cavities, such as Bragg-grating-based Fabry-Perot resonators, microspheres, microdisks, microtoroids, photonic crystal cavities, and ring resonators, have been exploited as high-sensitivity platforms for refractive index and label-free molecular sensing [16,17,21,83,[86][87][88]. In the Bragg-grating-based resonators a grated waveguide (GWG), which is a waveguide (WG) with a finite-length grated section, reflects incoming modes in a narrow wavelength region, defined by the geometry of the grating and the refractive indices of the constituting materials.…”