Wavelength-tunable luminescent gold nanoparticles generated by cooperation ligand exchange and their potential application in cellular imaging

Zhang, Zhengyong; Xu, Lingjia; Li, Huixiang; Kong, Jilie

doi:10.1039/c2ra21785f

Cited by 24 publications

(24 citation statements)

References 45 publications

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“…2,[19][20][21][22] There are numerous synthetic routes to prepare ultra-small gold nanoparticles, many of them utilizing the aurophilicity of thiol groups to achieve efficient capping in combination with strongly reducing agents to generate clusterlike gold nanoparticles. 14,[23][24][25][26] Recently, ultra-small silver nanoparticles exhibiting autouorescence have been prepared with methods and ligands as in the synthesis of gold clusters. 18,[27][28][29][30] Frequently used capping agents are on the one hand proteins (e.g.…”

Section: Introductionmentioning

confidence: 99%

An easy synthesis of autofluorescent alloyed silver–gold nanoparticles

et al. 2014

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A one-pot synthesis of fluorescent bimetallic silver-gold nanoparticles in aqueous medium is presented. Carboxylic acid-functionalized nanoparticles were prepared with different metal compositions from 90 : 10 to 10 : 90 (n : n) for silver : gold with a diameter of 1.8 AE 0.4 nm. Pure silver and gold nanoparticles were prepared for comparison. Spectroscopic analyses showed that the ligand, i.e. 11mercaptoundecanoic acid, binds to the particle surface by the thiol group, leaving the carboxylic acid accessible for further functionalization, e.g. by suitable coupling reactions. Nanoparticles with a silver content up to 60 : 40 showed autofluorescence with a large Stokes shift of about 250-300 nm (maximum wavelength of the emission between 608 nm and 645 nm). The intracellular localization of bimetallic silver-gold nanoparticles was studied in HeLa cells by confocal laser scanning microscopy (CLSM). The alloyed silver-gold nanoparticles showed no significant cytotoxicity at a metal concentration of 5 mg mL À1 for 24 h, but were cytotoxic to some degree at 50 mg mL À1 at higher silver content.

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Section: Introductionmentioning

confidence: 99%

An easy synthesis of autofluorescent alloyed silver–gold nanoparticles

et al. 2014

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“…40,41 It is well known that mitochondria involved in both apoptotic and necrotic cell death, so labeling and imaging mitochondria has attracted considerable interest. 42,43 However, conventional organic dyes used for mitochondrial imaging are strictly limited because of their poor cell penetration and/or photostability.…”

Section: Mitochondrial Imagingmentioning

confidence: 99%

Recent Progresses of Fluorescent Gold Nanoclusters in Biomedical Applications

Zhang¹,

Xiang²,

Fu³

2016

j nanosci nanotechnol

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Water-soluble fluorescent gold nanoclusters (AuNCs) have recently become one of the promising nanomaterials in biomedicine. Benefiting from their promising revolves around the broad versatility and biocompatibility, as well as unique physicochemical properties of high stability in biological media and excellent photostability, functionalized AuNCs have shown great potential in a broad range of biomedical applications, including cell and virus tracking, pathogen detection, bioimaging, drug delivery and theranostics. Here the advantages and drawbacks of fluorescent AuNCs in biomedical applications are discussed. Perhaps the most promising route is the co-engineering of AuNCs and functionalized molecules in synergistic conjugates, which might integrate the advantages of AuNCs and tagged molecules, and compensate the weaknesses of each other to meet the requirements for clinical application.

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“…The existence of a minute size range with great variations in the surface to volume ratio makes them very effective for the adsorption of harmful analytes on the exterior surface of particles. The higher surface area of ZnO has also provided an additional amount of surface active sites for the analytes [ 17 ]. The presence of more surface atoms has generated the active sensing layer for the materials to be sensed from the surrounding environment.…”

Section: Zno Nanomaterials For Sensing Applicationsmentioning

confidence: 99%

Chemical Sensing Applications of ZnO Nanomaterials

et al. 2018

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Recent advancement in nanoscience and nanotechnology has witnessed numerous triumphs of zinc oxide (ZnO) nanomaterials due to their various exotic and multifunctional properties and wide applications. As a remarkable and functional material, ZnO has attracted extensive scientific and technological attention, as it combines different properties such as high specific surface area, biocompatibility, electrochemical activities, chemical and photochemical stability, high-electron communicating features, non-toxicity, ease of syntheses, and so on. Because of its various interesting properties, ZnO nanomaterials have been used for various applications ranging from electronics to optoelectronics, sensing to biomedical and environmental applications. Further, due to the high electrochemical activities and electron communication features, ZnO nanomaterials are considered as excellent candidates for electrochemical sensors. The present review meticulously introduces the current advancements of ZnO nanomaterial-based chemical sensors. Various operational factors such as the effect of size, morphologies, compositions and their respective working mechanisms along with the selectivity, sensitivity, detection limit, stability, etc., are discussed in this article.

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Wavelength-tunable luminescent gold nanoparticles generated by cooperation ligand exchange and their potential application in cellular imaging

Cited by 24 publications

References 45 publications

An easy synthesis of autofluorescent alloyed silver–gold nanoparticles

An easy synthesis of autofluorescent alloyed silver–gold nanoparticles

Recent Progresses of Fluorescent Gold Nanoclusters in Biomedical Applications

Chemical Sensing Applications of ZnO Nanomaterials

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