Abstract:PurposeTo further improve analysis of the two-flash multifocal electroretinogram (2F-mfERG) in glaucoma in regard to structure–function analysis, using discrete wavelet transform (DWT) analysis.MethodsSixty subjects [35 controls and 25 primary open-angle glaucoma (POAG)] underwent 2F-mfERG. Responses were analyzed with the DWT. The DWT level that could best separate POAG from controls was compared to the root-mean-square (RMS) calculations previously used in the analysis of the 2F-mfERG. In a subgroup analysis… Show more
“…2 b)—in the nasal hemisphere of the VF (i.e., temporal hemisphere of the retina) and compared with that in the temporal hemisphere of the VF (i.e., nasal hemisphere of the retina) in the central 5°. We also calculated the correlations between the thresholds obtained from the corresponding VF area, OCT parameters, and the N/T [ 18 , 19 ].…”
Section: Methodsmentioning
confidence: 99%
“…4 ). We also calculated the correlations between the thresholds of the corresponding VF area, the mfPhNR/B, and OCT parameters [ 18 , 19 ]. Fig.…”
Background
The nasal to temporal amplitudes ratio (N/T) of multifocal electroretinography (mfERG) scans measured within 5° of the macula can be used to detect glaucomatous change. The photopic negative response (PhNR) of mfERG elicited by a circular stimulus centered on the fovea was significantly reduced in eyes with glaucoma. The PhNR to B-wave ratio (PhNR/B) is the optimal measure of the PhNR. However, clinical superiority for evaluating glaucoma patients has not been determined between N/T and PhNR/B yet.
Methods
For morphological assessments, ganglion cell complex (GCC) in six regions and the average were measured by optical coherence tomography (OCT). For functional assessment, Humphrey visual fields (VF) with mean sensitivities (MT) and mfERG scans with parameters of N/T and the multifocal photopic negative response to B-wave ratio (mfPhNR/B) were measured. Sixty-nine eyes of 44 glaucoma patients were included and correlations between mfERG parameters and OCT or VF parameters were evaluated.
Results
The mean age of patients was 59.4 years. The mean deviation for all eyes obtained with the VF 30–2 and VF 10–2 was − 7.00 and − 6.31 dB, respectively. Significant correlations between GCC thickness or VF parameter and the N/T were found, especially in the inferior and inforotemporal retinal areas corresponding to superior and superonasal VF sectors (GCC vs N/T; coefficient = − 7.916 and − 7.857, and MT vs N/T; coefficient = − 4.302 and − 4.437, in the inferior and inforotemporal retinal areas, respectively, all p values < 0.05). However, similar associations were not obtained between mfPhNR/B and OCT or VF parameters. The mfPhNR/B only in the inferotemporal sector was significantly correlated with the average thickness of GCC (coefficient = 4.823, P = 0.012).
Conclusions
The N/T was correlated with GCC and VF in more numbers of measurement areas than the mfPhNR/B in the current study, however, a future study modifying the stimuli and amplitudes to obtain the spatial correspondence to OCT and VF measurement will be required to evaluate the value of mfERG.
“…2 b)—in the nasal hemisphere of the VF (i.e., temporal hemisphere of the retina) and compared with that in the temporal hemisphere of the VF (i.e., nasal hemisphere of the retina) in the central 5°. We also calculated the correlations between the thresholds obtained from the corresponding VF area, OCT parameters, and the N/T [ 18 , 19 ].…”
Section: Methodsmentioning
confidence: 99%
“…4 ). We also calculated the correlations between the thresholds of the corresponding VF area, the mfPhNR/B, and OCT parameters [ 18 , 19 ]. Fig.…”
Background
The nasal to temporal amplitudes ratio (N/T) of multifocal electroretinography (mfERG) scans measured within 5° of the macula can be used to detect glaucomatous change. The photopic negative response (PhNR) of mfERG elicited by a circular stimulus centered on the fovea was significantly reduced in eyes with glaucoma. The PhNR to B-wave ratio (PhNR/B) is the optimal measure of the PhNR. However, clinical superiority for evaluating glaucoma patients has not been determined between N/T and PhNR/B yet.
Methods
For morphological assessments, ganglion cell complex (GCC) in six regions and the average were measured by optical coherence tomography (OCT). For functional assessment, Humphrey visual fields (VF) with mean sensitivities (MT) and mfERG scans with parameters of N/T and the multifocal photopic negative response to B-wave ratio (mfPhNR/B) were measured. Sixty-nine eyes of 44 glaucoma patients were included and correlations between mfERG parameters and OCT or VF parameters were evaluated.
Results
The mean age of patients was 59.4 years. The mean deviation for all eyes obtained with the VF 30–2 and VF 10–2 was − 7.00 and − 6.31 dB, respectively. Significant correlations between GCC thickness or VF parameter and the N/T were found, especially in the inferior and inforotemporal retinal areas corresponding to superior and superonasal VF sectors (GCC vs N/T; coefficient = − 7.916 and − 7.857, and MT vs N/T; coefficient = − 4.302 and − 4.437, in the inferior and inforotemporal retinal areas, respectively, all p values < 0.05). However, similar associations were not obtained between mfPhNR/B and OCT or VF parameters. The mfPhNR/B only in the inferotemporal sector was significantly correlated with the average thickness of GCC (coefficient = 4.823, P = 0.012).
Conclusions
The N/T was correlated with GCC and VF in more numbers of measurement areas than the mfPhNR/B in the current study, however, a future study modifying the stimuli and amplitudes to obtain the spatial correspondence to OCT and VF measurement will be required to evaluate the value of mfERG.
“…We calculated the N/T-namely, the ratio of the mfERG P1 amplitudes of the rst slice of the second-order kernel (Figure 2b)-in the nasal hemisphere of the VF (i.e., temporal hemisphere of the retina) and compared with that in the temporal hemisphere of the VF (i.e., nasal hemisphere of the retina) in the central 5°. We also calculated the correlations between the thresholds obtained from the corresponding VF area, OCT parameters, and the N/T [18,19].…”
Section: Nasal To Temporal Amplitude Ratio Analyses Of Mferg Scansmentioning
confidence: 99%
“…To compare the mfPhNR/B with the corresponding VF ndings, we measured the thresholds with the HFA 30-2 and averaged for the same sectors according to the distance from the macula within the central 20° ( Figure 4). We also calculated the correlations between the thresholds of the corresponding VF area, the mfPhNR/B, and OCT parameters [18,19].…”
Background:
The nasal to temporal amplitudes ratio (N/T) of multifocal electroretinography (mfERG) scans measured within 5° of the macula can be used to detect glaucomatous change. The photopic negative response (PhNR) of mfERG elicited by a circular stimulus centered on the fovea was significantly reduced in eyes with glaucoma. The PhNR to B-wave ratio (PhNR/B) is the optimal measure of the PhNR. However, clinical superiority for evaluating glaucoma patients has not been determined between N/T and PhNR/B yet.
Methods: For morphological assessments, ganglion cell complex (GCC) in six regions and the average were measured by optical coherence tomography (OCT). For functional assessment, Humphrey visual fields (VF) with mean sensitivities (MT) and mfERG scans with parameters of N/T and the multifocal photopic negative response to B-wave ratio (mfPhNR/B) were measured. Sixty-nine eyes of forty-four glaucoma patients were included and correlations between mfERG parameters and OCT or VF parameters were evaluated.
Results: The mean age of patients was 59.4 years. The mean deviation for all eyes obtained with the VF 30-2 and VF 10-2 was -7.00 and -6.31 dB, respectively. Significant correlations between GCC thickness or VF parameter and the N/T were found, especially in the inferior and inforotemporal retinal areas corresponding to superior and superonasal VF sectors (GCC vs N/T; coefficient = -7.916 and -7.857, and MT vs N/T ; coefficient = -4.302 and -4.437, in the inferior and inforotemporal retinal areas, respectively, all p values < 0.05). However, similar associations were not obtained between mfPhNR/B and OCT or VF parameters. The mfPhNR/B only in the inferotemporal sector was significantly correlated with the average thickness of GCC (coefficient = 4.823, P = 0.012).
Conclusions: The N/T is better parameter than PhNR/B for the assessment of glaucomatous eyes in the current study’s measurement conditions. A future study modifying the stimuli and amplitudes to obtain the spatial correspondence to OCT and VF measurement will be required to evaluate the value of mfERG.
“…В другом исследовании чувствительность была представлена на уровне 30-45 %, а специфичность -85 %, выше относительно КП [47]. В других публикациях сообщается, что чувствительность МЗВП при глаукоме соответствовала 97,5 %, а при ранней глаукоме -до 95 % [48].…”
The review is focused on modern methods of instrumental diagnostics of primary open-angle glaucoma. Diagnostic possibilities and informativeness of objective measurable parameters are discussed with regard to special criteria, called clinical endpoints.
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