WAY100635 and latent inhibition in the rat: selective effects at preexposure

Killcross, Simon; Stanhope, Kelly J.; Dourish, C T; Piras, G

doi:10.1016/s0166-4328(97)02309-7

Cited by 20 publications

(10 citation statements)

References 33 publications

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“…1995b). Another 5‐HT 1A antagonist N‐(2‐(4‐(2‐methoxyphenyl)‐1‐piperazinyl)‐N‐(2‐pyridyl)cyclohexane carboxamine maleate (WAY100635) can enhance the conditioned stimulus pre‐exposure effect in inducing latent inhibition (Killcross et al. 1997a) and attenuate impairments in performing a visuospatial task caused by fornix transection (Harder et al.…”

Section: Introductionsupporting

confidence: 94%

“…Conversely, the 5-HT 1A antagonist N-tert-butyl-3-4-(2methoxyphenyl)piperazin-1-yl-2-phenylpropanamide dihydrochloride (WAY100135) ameliorates the spatial learning deficit caused by scopolamine infused into the hippocampus (Carli et al, 1995b). Another 5-HT 1A antagonist N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)-N-(2-pyridyl)cyclohexane carboxamine maleate (WAY100635) can enhance the conditioned stimulus pre-exposure effect in inducing latent inhibition (Killcross et al, 1997a) and attenuate impairments in performing a visuospatial task caused by fornix transection (Harder et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

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Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors

Liang

1999

Eur J of Neuroscience

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The present study investigated the effect of buspirone on memory formation in an aversive learning task. Male Wistar rats were trained on the inhibitory avoidance task and tested for retention 1 day after training. They received peripheral or intra-amygdala administration of buspirone or other 5-HT1A drugs either before or after training. Results indicated that pretraining systemic injections of buspirone caused a dose-dependent retention deficit; 5. 0 mg/kg had a marked effect and 1.0 mg/kg had no effect. Post-training injections of the drug caused a time-dependent retention deficit, which was not due to a state-dependent effect on retrieval. When training in the inhibitory avoidance task was divided into a context-training phase and a shock-training phase, buspirone impaired retention only when administered in the shock-training phase, suggesting that the drug influenced memory processing of affective events. Further results indicated that post-training intra-amygdala infusion of buspirone or the 5-HT1A agonist 8-hydroxy-di-n-propylaminotetralin (8-OH-DPAT) caused a time-dependent and dose-dependent retention deficit. Post-training intra-amygdala infusion of the 5-HT1A antagonist WAY100635 (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)-N-(2-pyridyl) cyclohexane carboxamine maleate) attenuated the memory-impairing effects of buspirone. These findings suggest that buspirone may modulate memory storage processes in the inhibitory avoidance task through an action on amygdaloid 5-HT1A receptors.

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Section: Introductionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors

Liang

1999

Eur J of Neuroscience

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“…The latter has been suggested to mediate DOI's hallucinogenic action and could be another potential mechanism of its LI disrupting effect. Killcross et al (1997) reported that the 5HT 1A antagonist WAY100635 potentiated LI, and also this effect was exerted at the pre-exposure stage. Importantly, LI potentiation was also obtained when WAY 100635 was given in both stages but not when given in conditioning, demonstrating conclusively that this effect was pre-exposure-based.…”

Section: The Serotonergic Systemmentioning

confidence: 95%

The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment

2003

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Different drug and lesion manipulations produce two poles of abnormality in LI, namely, disrupted LI under conditions which lead to LI in normal rats, and abnormally persistent LI under conditions which disrupt it in normal rats. Disrupted and persistent LI are differentially responsive to APDs, with the former reversed by both typical and atypical APDs and the latter selectively reversed by atypical APDs. It is suggested that this "two-headed LI model" mimics two extremes of deficient cognitive switching seen in schizophrenia, excessive and retarded switching between associations, mediated by dysfunction of different brain circuitries, and can serve to model positive symptoms of schizophrenia and typical antipsychotic action, as well as negative symptoms of schizophrenia and atypical antipsychotic action.

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“…Drug studies have greatly advanced our understanding of the bases of disrupted LI by the use of treatments selectively introduced at the pre-exposure and conditioning stages of the procedure (Feldon, Shofel & Weiner, 1991;Feldon & Weiner, 1989;Hitchcock, Lister, Fischer & Wettstein, 1997;Killcross, Stanhope, Dourish & Piras, 1997;LaCroix, Spinelli, Broersen & Feldon, 2000;Weiner, Lubow & Feldon, 1984). Thus, within the LI procedure itself, dissociations in terms of where drugs are effective tell us through which mechanisms they are effective.…”

Section: Different Psychopharmacology?mentioning

confidence: 99%

“…The effects of drugs on LI mediated at the pre-exposure phase have been demonstrated with compounds that affect GABA (Feldon & Weiner, 1989;LaCroix et al, 2000), as well as with serotonergic compounds (Hitchcock et al, 1997;354 Helen J. Cassaday and Paula M. Moran Killcross et al, 1997;Weiner, 2003, for review). On the other hand, it is much harder to modulate LI with dopaminergic treatments that are confined to the pre-exposure phase (Weiner, 2003;Weiner et al, 1984.…”

Section: Different Psychopharmacology?mentioning

confidence: 99%

Latent inhibition and other salience modulation effects: same neural substrates?

Cassaday¹,

Moran²

2010

Latent Inhibition

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WAY100635 and latent inhibition in the rat: selective effects at preexposure

Cited by 20 publications

References 33 publications

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors

The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment

Latent inhibition and other salience modulation effects: same neural substrates?

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WAY100635 and latent inhibition in the rat: selective effects at preexposure

Cited by 20 publications

References 33 publications

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT1A receptors

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT1A receptors

The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment

Latent inhibition and other salience modulation effects: same neural substrates?

Contact Info

Product

Resources

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Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors

Pre‐ or post‐training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5‐HT_1A receptors