Ways of Regulation of Release of Medicinal Substances from the Chitosan Films

Abstract

The article studies the chitosan films obtained by applying acetic acid and two antibiotics of cephalosporin and aminoglycoside type. It investigates the possibility of their transport properties regulation in the sphere of medicines manufacture. This regulation can be carried out by films with thermal modification implying the heating of formed films at the temperature of about 120 °C and reaction with sodium dodecyl sulphate. The article shows that the antibiotics release from films will be determined by the amount of antibiotics connected with chitosan by hydrogen bonds, on the one hand, and by the state of the polymer matrix, on the other hand.