This article explores some of the understandings of “science” that are often employed in the literature on “science and Eastern religions.” These understandings crucially shape the raging debates between the avid proponents and the keen detractors of the thesis that Eastern forms of spirituality are uniquely able to subsume the sciences into their metaphysical–axiological horizons. More specifically, the author discusses some of the proposed relations between “science” and “Eastern religions” by highlighting three themes: (a) the relation between science and metaphysics, (b) the relation between science and experience, and (c) the European origins of science. The analysis of these relations requires a methodological inquiry into some of the culturally freighted valences of “science,” “metaphysics,” and “experience.”