WBC count predicts heart failure in diabetes and coronary artery disease patients: a retrospective cohort study

Kawabe, Atsuhiko; Yasu, Takanori; Morimoto, Takeshi; Tokushige, Akihiro; Momomura, Shin‐ichi; Sakakura, Kenichi; Node, Koichi; Inoue, Taku; Ueda, Shinichiro

doi:10.1002/ehf2.13513

Cited by 21 publications

(23 citation statements)

References 43 publications

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“…45,46 In addition, in patients with type 2 diabetes and coronary heart disease, higher WBC counts are predictors of atrial fibrillation, all-cause death, and hospitalization for acute myocardial infarction. 47 In the present study, we demonstrated that elevated WBC counts are an independent risk factor of i-IGT. The elevated WBC counts in patients with i-IGT further suggest a role for chronic inflammation in the progression of i-IGT.…”

Section: Discussionsupporting

confidence: 62%

Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China

Tian¹,

Li²,

Liu³

et al. 2021

DMSO

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Introduction Isolated impaired glucose tolerance (i–IGT) is a subtype of prediabetes in which an individual demonstrates elevated 2-h post-glucose load glucose levels but normal fasting plasma glucose levels. However, few studies have explored the prevalence and risk factors of i–IGT among adults in rural China. Thus, we aimed to explore the prevalence and risk factors of i–IGT among adults ≥50 years old in a low-income, rural population in China. Materials and Methods Individuals aged ≥50 years with normal fasting plasma glucose levels were included in the final analysis. Fasting and 2-h venous blood samples were collected to assess the selected parameter measurements. Results A total of 2175 individuals were included in this study. The i–IGT prevalence was 22.9% and significantly higher among females than among males (P<0.05). Older age [odds ratio (OR), 1.606; 95% confidence interval (CI), 1.101–2.342; P=0.014), hypertension (OR, 1.554; 95% CI, 1.152–2.019; P=0.004), and central obesity (OR, 1.395; 95% CI, 1.099–1.771; P=0.006) were associated with i–IGT. Moreover, white blood cell (OR, 1.089; 95% CI, 1.009–1.175; P=0.029), high-sensitivity C-reactive protein (OR, 1.049; 95% CI, 1.020–1.078; P=0.001), serum uric acid (OR, 1.0003; 95% CI, 1.001–1.004; P=0.001), triglyceride (OR, 1.540; 95% CI, 1.105–2.147; P=0.011), and alanine aminotransferase (OR, 1.012; 95% CI, 1.004–1.021; P=0.004) levels were also linked to i–IGT in the analyzed population. Conclusion Health promotion education and a standardized approach to managing body weight, BP, and lipid and uric acid levels would benefit this low-income population in rural China for reducing the risk of cardiovascular disease.

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Section: Discussionsupporting

confidence: 62%

Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China

Tian¹,

Li²,

Liu³

et al. 2021

DMSO

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“…CRP and FIB are acute-phase reactants induced by inflammatory cytokines and exert proinflammatory effects on the vascular endothelium to promote thrombotic states ( 8 , 9 ). Another accessible inflammatory marker, WBC, is an independent predictor of hospitalization for heart failure, acute myocardial infarction, and all-cause death in patients with CAD ( 10 ). A low-grade inflammation (INFLA) score, which comprises hs-CRP, WBC, platelet count, and granulocyte-to-lymphocyte ratio ( 11 ), has been used in the Moli-sani cohort and is independently associated with adverse health risks, particularly in individuals with diabetes and cardiovascular disease (CVD) ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Metabolic Profiling of Inflammation Indicated Key Roles of Glycerophospholipid and Arginine Metabolism in Coronary Artery Disease

Zhu

Mai

et al. 2022

Front. Immunol.

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BackgroundSystemic immune inflammation is a key mediator in the progression of coronary artery disease (CAD), concerning various metabolic and lipid changes. In this study, the relationship between the inflammatory index and metabolic profile in patients with CAD was investigated to provide deep insights into metabolic disturbances related to inflammation.MethodsWidely targeted plasma metabolomic and lipidomic profiling was performed in 1,234 patients with CAD. Laboratory circulating inflammatory markers were mainly used to define general systemic immune and low-grade inflammatory states. Multivariable-adjusted linear regression was adopted to assess the associations between 860 metabolites and 7 inflammatory markers. Least absolute shrinkage and selection operator (LASSO) logistic-based classifiers and multivariable logistic regression were applied to identify biomarkers of inflammatory states and develop models for discriminating an advanced inflammatory state.ResultsMultiple metabolites and lipid species were linearly associated with the seven inflammatory markers [false discovery rate (FDR) <0.05]. LASSO and multivariable-adjusted logistic regression analysis identified significant associations between 45 metabolites and systemic immune-inflammation index, 46 metabolites and neutrophil–lymphocyte ratio states, 32 metabolites and low-grade inflammation score, and 26 metabolites and high-sensitivity C-reactive protein states (P < 0.05). Glycerophospholipid metabolism and arginine and proline metabolism were determined as key altered metabolic pathways for systemic immune and low-grade inflammatory states. Predictive models based solely on metabolite combinations showed feasibility (area under the curve: 0.81 to 0.88) for discriminating the four parameters that represent inflammatory states and were successfully validated using a validation cohort. The inflammation-associated metabolite, namely, β-pseudouridine, was related to carotid and coronary arteriosclerosis indicators (P < 0.05).ConclusionsThis study provides further information on the relationship between plasma metabolite profiles and inflammatory states represented by various inflammatory markers in CAD. These metabolic markers provide potential insights into pathological changes during CAD progression and may aid in the development of therapeutic targets.

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“…HF events were reported to the study office and subsequently adjudicated by the event evaluation committee. 14 …”

Section: Methodsmentioning

confidence: 99%

“…HF in our study was principally diagnosed according to the diagnostic criteria of the Framingham Heart Study13 and based on information on medical records, that is, response to treatments with diuretics and vasodilators. HF events were reported to the study office and subsequently adjudicated by the event evaluation committee 14…”

Section: Methodsmentioning

confidence: 99%

Women with type 2 diabetes and coronary artery disease have a higher risk of heart failure than men, with a significant gender interaction between heart failure risk and risk factor management: a retrospective registry study

Fujita

Morimoto

Tokushige

et al. 2022

BMJ Open Diab Res Care

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IntroductionWomen are generally perceived to have a lower risk of cardiovascular events than men, despite a lack of data, particularly among patients with diabetes. Here, we investigated gender differences in the risk of heart failure (HF) events in patients with type 2 diabetes and coronary artery disease (CAD). We also assessed the association between cardiovascular risk factor management and HF events.Research design and methodsThis retrospective registry study enrolled consecutive patients with both type 2 diabetes and CAD, based on angiography records and medical charts at 70 teaching hospitals in Japan, from January 2005 to December 2015.ResultsThe registry included 7785 patients with a mean follow-up period of 1328 days. The mean age of the patients was 67.6 years. The risk of hospitalization for HF in patients with both type 2 diabetes and CAD was significantly higher among women than among men (HR, 1.26, 95% CI 1.06 to 1.50). The relationship between HF risk and achieved low-density lipoprotein cholesterol (LDL-c) and systolic blood pressure, but not hemoglobin A1c, differed between women and men, with statistically significant interactions (p=0.009 and p=0.043, respectively).ConclusionsWomen with type 2 diabetes and CAD have a higher risk of HF than men. A significant gender interaction was observed in the association between HF risk and risk factor management, particularly regarding LDL-c and systolic blood pressure. The effectiveness of risk factor management may differ between men and women regarding HF prevention among patients with type 2 diabetes and CAD.

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WBC count predicts heart failure in diabetes and coronary artery disease patients: a retrospective cohort study

Cited by 21 publications

References 43 publications

Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China

Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China

Comprehensive Metabolic Profiling of Inflammation Indicated Key Roles of Glycerophospholipid and Arginine Metabolism in Coronary Artery Disease

Women with type 2 diabetes and coronary artery disease have a higher risk of heart failure than men, with a significant gender interaction between heart failure risk and risk factor management: a retrospective registry study

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