2014
DOI: 10.1155/2014/808307
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We Are Ageing

Abstract: Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have been proposed. Also, some theories of ageing were introduced. To date, the most promising leads for longevity are caloric restriction, particularly target of rapamycin (TOR), sirtuins, hexarelin and hormetic responses… Show more

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Cited by 25 publications
(19 citation statements)
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“…But while hearing loss and/or cognitive decline continue to be common among the elderly, that does not necessarily mean that aging and hearing loss or dementia go hand in hand: healthy aging is possible at every stage of life [Kolovou et al, 2014].…”
Section: Epidemiologymentioning
confidence: 99%
“…But while hearing loss and/or cognitive decline continue to be common among the elderly, that does not necessarily mean that aging and hearing loss or dementia go hand in hand: healthy aging is possible at every stage of life [Kolovou et al, 2014].…”
Section: Epidemiologymentioning
confidence: 99%
“…In particular, growth hormone, insulin, insulin like growth factor-1, and target of rapamycin pathways have been actively investigated, and sirtuin genes have been identified as ‘longevity genes’ that are upregulated in animals whose lives have been prolonged by caloric restriction [2]. Sirtuins are NAD + -dependent protein deacetylases that regulate various downstream molecules and are highly conserved from yeast to human [3].…”
Section: Introductionmentioning
confidence: 99%
“…In this study, we have investigated mortality data to test whether men age faster than women, as was previously suggested by several authors 2,[19][20][21] The potential weakness of our work is that our analysis of mortality data does not distinguish between intrinsic and extrinsic sources of mortality. There is a great body of literature focusing on partitioning mortality to intrinsic and extrinsic mortality 22,23 .…”
Section: Discussionmentioning
confidence: 99%
“…We investigated mortality data to test whether men age faster than women, as previously suggested in several studies. 2,[19][20][21] they are ultimately highly constrained models which may sometimes produce incorrect results. We therefore also compared the pace of aging between the sexes using non-parametric approaches.…”
Section: Discussionmentioning
confidence: 99%