The relationship between mission and spirituality for sincere disciples of Jesus involves dimensions that include the biblical, the theological, the historical, the missiological, the spiritual, and the practical. This article will offer a contribution to the biblical discussion, specifically from the Fourth Gospel and through the lens of the motif of agency. This motif can inform what Jesus meant when he said, “Just as the Father has sent me, so I send you” (John 20:21).1 As a result, conclusions can be drawn in regard to the place of mission in Johannine spirituality and discipleship.