AND PERSPECTIVEThis study examined the impact of evidence concerning the presence of: a) a biomedical basis for pain, and b) psychosocial influences, on practitioner appraisals of patient pain experiences.Further, the potential moderating role of patient pain behaviour was examined. In an online study, 52 general practitioners (GPs) and 46 physiotherapists (PTs) viewed video sequences of 4 patients manifesting pain, with accompanying vignettes describing presence or absence of medical evidence and psychosocial influences. Participants estimated pain intensity, daily interference, felt sympathy, effectiveness of pain medication, self-efficacy, their likability and suspicions of deception. Primary findings indicated lower perceived pain and daily interference, less sympathy, lower expectations of medication impact, and less self-efficacy when medical evidence was absent. The same results were found when psychosocial influences were present, but only when the patient displayed higher levels of pain behavior.Further, absence of medical evidence was related to less positive evaluations of the patients and to higher beliefs in deception in both professions. The presence of psychosocial influences was related to less positive evaluations and higher beliefs in deception in both professions. In sum, a range of contextual factors influence healthcare practitioner responses to patient pain. Implications for caregiving behavior are discussed.Perspective: The present study indicates that in the absence of clear medical evidence and in the presence of psychosocial influences patient pain might be taken less seriously by healthcare practitioners. These findings are important to further understand the difficulties that relate to the clinical encounter between pain patients and healthcare practitioners.