In this interview, Adele Clarke and Isabel Fletcher discuss the different routes that led Clarke to science and technology studies (STS), the field’s increasing engagement with biomedical topics, and her perspectives on its character today. Clarke describes how women’s health activism and teaching feminist critiques of bioscience/biomedicine led her to participate in academic networks now known as feminist STS and trans-national reproduction studies. She reflects on the importance of inter-/trans-disciplinary collaboration in her work, but also raises concerns that the rapid expansion of the field has resulted in inadequate training for newcomers in the “theory-method packages” of STS, and hence poor quality scholarship. For her, the future of STS lies in approaches analyzing the complex intersections between technoscience, gender, race, (post)coloniality, and indigenous knowledges, and in its expansion beyond Europe and North America, to Asia, Central and South America, and Africa. In her following reflection, Isabel Fletcher considers the importance of inter/trans-disciplinarity for STS and highlights the role a politically engaged STS can play in imagining alternative and better worlds.