Weak combined magnetic field affects basic and morphine-induced rat's EEG

Vorobyov, Vasily; Sosunov, Evgeni Alekseevitch; Kukushkin, Nikolai I.; Lednev, V. V.

doi:10.1016/s0006-8993(97)01228-6

Cited by 35 publications

(21 citation statements)

References 23 publications

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“…The changes in power EEG bands of control, for both skull and brain, were approximately similar with changes in power spectrum of recovery (compare Figures 2(a), (c) and Figures 3(a), (c)). Thus, the present EEG power spectrum findings are much consistence with previous studies [1,3,[14][15][16][17] which had been reported that ELF-MF affect significantly the brain electrical activity. They indicated that constant magnetic filed affects primarily Ca 2+ or, alternatively, K + -dependant biochemical reactions known to play key functions in regulation of the cellular activity; in particular, morphine-induced changes in cell functions.…”

Section: Discussionsupporting

confidence: 92%

The low frequency electromagnetic field on the rat EEG

Sallam¹

2012

JBPC

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The aim of the present study was to find out the effects of low frequency electromagnetic field (EMF) 50 Hz -10 mT on the rat electroencephalogram (EEG) recorded from the rat brain cortex and from the skull surface. The rats were, whole body, exposed to this EMF intensity one hour daily for 7 days. Recovery study was done after one week from stopping the EMF exposure. The effects of the filed were estimated by compression of the averaged EEG frequency spectra in the range of frequencies between 0.2 -0.7 Hz and by comparison of amplitude of EEG waves in control, exposed to EMF and recovery animals. Statistically significant effects of EMF were observed both in EEG amplitude and power reduction at most EEG frequencies. Also, noticeable variations were observed in normal values of maximum amplitude and number of successive EEG epochs recorded from brain and skull surfaces after exposure to ELF magnetic fields. These results show that a weak low EMF can influence the spontaneous electrical rat brain activity in the animals subjected to the EMF.

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Section: Discussionsupporting

confidence: 92%

The low frequency electromagnetic field on the rat EEG

Sallam¹

2012

JBPC

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“…1). It was previously reported that SMFs can increase the mobilization of intracellular Ca 2þ in mammalian cultured cells, which can directly or indirectly affect the organization of microfilaments and microtubules, cell shape, and the distribution of surface carbohydrate residues [Blackman et al, 1985;Vorobyov et al, 1998;Lange, 2000;Dini and Abbro, 2005;Silva et al, 2006]. Consequently, such data suggest that the actin-based core in microvilli (which are regulated by Ca 2þ ) functions as a cellular interaction site for SMFs [Gartzke and Lange, 2002].…”

Section: Discussionmentioning

confidence: 94%

The effect of high strength static magnetic fields and ionizing radiation on gene expression and DNA damage in Caenorhabditis elegans

Kimura

Takahashi

Suzuki

et al. 2008

Bioelectromagnetics

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Magnetic resonance imaging with high static magnetic fields (SMFs) has become widely used for medical imaging purposes because SMFs cause fewer genotoxic side effects than ionizing radiation (IR). However, the effect of exposure to high SMFs on global transcription is little understood. We demonstrate that genes involved in motor activity, actin binding, cell adhesion, and cuticles are transiently and specifically induced following exposure to 3 or 5 T SMF in the experimental model metazoan Caenorhabditis elegans. In addition, transient induction of hsp12 family genes was observed after SMF exposure. The small-heat shock protein gene hsp16 was also induced but to a much lesser extent, and the LacZ-stained population of hsp-16.1::lacZ transgenic worms did not significantly increase after exposure to SMFs with or without a second stressor, mild heat shock. Several genes encoding apoptotic cell-death activators and secreted surface proteins were upregulated after IR, but were not induced by SMFs. Real-time quantitative RT-PCR analyses for 12 of these genes confirmed these expression differences between worms exposed to SMFs and IR. In contrast to IR, exposure to high SMFs did not induce DNA double-strand breaks or germline cell apoptosis during meiosis. These results suggest that the response of C. elegans to high SMFs is unique and capable of adjustment during long exposure, and that this treatment may be less hazardous than other therapeutic tools.

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“…Several studies that have utilized shielding or active zeroing of the geomagnetic field as a control group for investigation of various biological effects of exogenous magnetic fields, do not allow an evaluation of the effects of the near-zero magnetic condition per se because they do not include a group of animals exposed to the ambient magnetic field (e.g. Michael 1977;Weiss et al 1992;Dawson et al 1998;Rojavin et al 1998;Vorobyov et al 1998;Thomas et al 1997aThomas et al ,b, 1998. Few studies have examined the biological effects of shielding the ambient magnetic field (Kopanev et al 1979;Chew & Brown 1989;Asashima et al 1991;Tipping et al 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Kopanev et al 1979;Asashima et al 1991) or used as the 'sham' control group (e.g. Dawson et al (1998), Rojavin et al (1998) and Weiss et al (1992) used -metal shielding, while Vorobyov et al (1998) and Thomas et al (1997aThomas et al ( ,b, 1998) used a vector-nulled magnetic field). It should be noted that the -metal box attenuates both the ambient static as well as the ambient time-varying ELF magnetic fields, while the vector-nulling (zeroing) approach zeroes only the static component.…”

Section: Introductionmentioning

confidence: 99%

Shielding, but not zeroing of the ambient magnetic field reduces stress-induced analgesia in mice

Choleris

Seppia

Thomas

et al. 2002

Proc. R. Soc. Lond. B

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Magnetic field exposure was consistently found to affect pain inhibition (i.e. analgesia). Recently, we showed that an extreme reduction of the ambient magnetic and electric environment, by -metal shielding, also affected stress-induced analgesia (SIA) in C57 mice. Using CD1 mice, we report here the same findings from replication studies performed independently in Pisa, Italy and London, ON, Canada. Also, neither selective vector nulling of the static component of the ambient magnetic field with Helmholtz coils, nor copper shielding of only the ambient electric field, affected SIA in mice. We further show that a pre-stress exposure to the -metal box is necessary for the anti-analgesic effects to occur. The differential effects of the two near-zero magnetic conditions may depend on the elimination (obtained only by -metal shielding) of the extremely weak time-varying component of the magnetic environment. This would provide the first direct and repeatable evidence for a behavioural and physiological effect of very weak time-varying magnetic fields, suggesting the existence of a very sensitive magnetic discrimination in the endogenous mechanisms that underlie SIA. This has important implications for other reported effects of exposures to very weak magnetic fields and for the theoretical work that considers the mechanisms underlying the biological detection of weak magnetic fields.

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Weak combined magnetic field affects basic and morphine-induced rat's EEG

Cited by 35 publications

References 23 publications

The low frequency electromagnetic field on the rat EEG

The low frequency electromagnetic field on the rat EEG

The effect of high strength static magnetic fields and ionizing radiation on gene expression and DNA damage in Caenorhabditis elegans

Shielding, but not zeroing of the ambient magnetic field reduces stress-induced analgesia in mice

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