Weak resonance effects of THz wave transimission in nerve cell

电子科技大学物理电子学院,; 电子科技大学,

doi:10.7498/aps.70.20211677

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…The fitted parameters were brought into Eq. 1 ( Guo et al, 2021 ) to obtain the relationship between the relative permittivity of the neuronal membrane and frequency ( Figure 1C ).

where

is angular frequency;

is high frequency limit relative dielectric constant;

is static relative dielectric constant;

is the median value;

and

are relaxation times.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, tiny organelles exhibit only diffraction and bypassing behavior, and therefore their effects are also neglected in the calculations. The relative permittivity of the physiological fluids within neurons can be obtained from the literature ( Guo et al, 2021 ). After fitting through the second-order Debye model, the Debye parameters are shown in Table 2 .…”

Section: Methodsmentioning

confidence: 99%

“…The fitted parameters were brought into Eq. 1 (Guo et al, 2021) to obtain the relationship between the relative permittivity of the neuronal membrane and frequency (Figure 1C).…”

Section: Neurons' Relative Dielectric Constantsmentioning

confidence: 99%

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The laws and effects of terahertz wave interactions with neurons

Gong

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: Terahertz waves lie within the energy range of hydrogen bonding and van der Waals forces. They can couple directly with proteins to excite non-linear resonance effects in proteins, and thus affect the structure of neurons. However, it remains unclear which terahertz radiation protocols modulate the structure of neurons. Furthermore, guidelines and methods for selecting terahertz radiation parameters are lacking.Methods: In this study, the propagation and thermal effects of 0.3–3 THz wave interactions with neurons were modelled, and the field strength and temperature variations were used as evaluation criteria. On this basis, we experimentally investigated the effects of cumulative radiation from terahertz waves on neuron structure. Results: The results show that the frequency and power of terahertz waves are the main factors influencing field strength and temperature in neurons, and that there is a positive correlation between them. Appropriate reductions in radiation power can mitigate the rise in temperature in the neurons, and can also be used in the form of pulsed waves, limiting the duration of a single radiation to the millisecond level. Short bursts of cumulative radiation can also be used. Broadband trace terahertz (0.1–2 THz, maximum radiated power 100 μW) with short duration cumulative radiation (3 min/day, 3 days) does not cause neuronal death. This radiation protocol can also promote the growth of neuronal cytosomes and protrusions.Discussion: This paper provides guidelines and methods for terahertz radiation parameter selection in the study of terahertz neurobiological effects. Additionally, it verifies that the short-duration cumulative radiation can modulate the structure of neurons.

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“…The fitted parameters were brought into Eq. 1 ( Guo et al, 2021 ) to obtain the relationship between the relative permittivity of the neuronal membrane and frequency ( Figure 1C ).

where

is angular frequency;

is high frequency limit relative dielectric constant;

is static relative dielectric constant;

is the median value;

and

are relaxation times.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The laws and effects of terahertz wave interactions with neurons

Gong

et al. 2023

Front. Bioeng. Biotechnol.

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“…In summary, the frequency of terahertz radiation is also an important factor affecting neurons by the mechanism of absorption and resonance of terahertz radiation by neurons. Since both the neuron size and the terahertz wavelength are on the order of micrometers, they are equipped to interact [ 78 , 79 , 80 ]. In addition, the resonance peaks between biological macromolecules are different, so there are differences in the effects of different frequencies of terahertz radiation on neurons.…”

Section: The Impact Of Terahertz Radiation On Neuronal Morphology And...mentioning

confidence: 99%

Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties

Ma,

Ding,

Zhou

et al. 2024

Brain Sciences

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Terahertz radiation falls within the spectrum of hydrogen bonding, molecular rotation, and vibration, as well as van der Waals forces, indicating that many biological macromolecules exhibit a strong absorption and resonance in this frequency band. Research has shown that the terahertz radiation of specific frequencies and energies can mediate changes in cellular morphology and function by exciting nonlinear resonance effects in proteins. However, current studies have mainly focused on the cellular level and lack systematic studies on multiple levels. Moreover, the mechanism and law of interaction between terahertz radiation and neurons are still unclear. Therefore, this paper analyzes the mechanisms by which terahertz radiation modulates the nervous system, and it analyzes and discusses the methods by which terahertz radiation modulates neurons. In addition, this paper reviews the laws of terahertz radiation’s influence on neuronal morphology and kinetic properties and discusses them in detail in terms of terahertz radiation frequency, energy, and time. In the future, the safety of the terahertz radiation system should be considered first to construct the safety criterion of terahertz modulation, and the spatial resolution of the terahertz radiation system should be improved. In addition, the systematic improvement of the laws and mechanisms of terahertz modulation of the nervous system on multiple levels is the key to applying terahertz waves to neuroscience. This paper can provide a platform for researchers to understand the mechanism of the terahertz–nervous system interaction, its current status, and future research directions.

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Hyperspectral Metachip‐Based 3D Spatial Map for Cancer Cell Screening and Quantification

Zhao,

Tang,

et al. 2024

Advanced Materials

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In this paper, compact terahertz (THz) metachips for hyperspectral screening and quantitative evaluation of human cancer cells is reported. This pixelated resonant metachips feature the resonance channel from 1 and 3 THz frequency with a record‐high quality factor (up to 230). Through the interactions of various cancer cells of different concentrations, high‐dimensional spectral signatures are obtained, which are further transformed into a spatial map for labelling and quantification purposes. The screening of up to 15 cancer cells is experimentally reported, with very high detecting accuracy of 93.33% and with attractive quantitative concentration sensitivity up to 1320 kHz cell mL−1. This hyperspectral metachips are low‐cost, highly compact, and label‐free for fast, high‐throughput and high‐sensitivity detections and evaluation of human cancer cells. This technology does not require clinical experience, representing an accessible technology for early diagnosis of cancer.

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Weak resonance effects of THz wave transimission in nerve cell

Cited by 5 publications

References 17 publications

The laws and effects of terahertz wave interactions with neurons

The laws and effects of terahertz wave interactions with neurons

Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties

Hyperspectral Metachip‐Based 3D Spatial Map for Cancer Cell Screening and Quantification

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