Weaker semantic language lateralization associated with better semantic language performance in healthy right‐handed children

Bartha‐Doering, Lisa; Kollndorfer, Kathrin; Kasprian, Gregor; Novak, Astrid; Schuler, Anna‐Lisa; Fischmeister, Florian Ph. S.; Alexopoulos, Johanna; Gaillard, William D.; Prayer, Daniela; Seidl, Rainer; Berl, Madison M.

doi:10.1002/brb3.1072

Cited by 23 publications

(22 citation statements)

References 87 publications

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“…Previous literature in healthy children and adolescents found an association between language lateralization and functioning, but conflicting findings were reported regarding the nature of this relationship: some studies found a positive correlation between language lateralization towards the left hemisphere and verbal abilities, 43, 44 whereas others reported better language performance related to less lateralization and more involvement of the contralateral hemisphere. 29, 30, 45–47 The contradictory findings of these studies may be the result of different imaging methods and different tasks testing different functions. The relationship between lateralization and cognitive functioning has been reported as dependent on task demands.…”

Section: Discussionmentioning

confidence: 99%

Atypical language representation is unfavorable for language abilities following childhood stroke

Bartha‐Doering

Novak

Kollndorfer

et al. 2019

European Journal of Paediatric Neurology

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Brain plasticity has often been quoted as a reason for the more favorable outcome in childhood stroke compared to adult stroke. We investigated the relationship between language abilities and language localization in childhood stroke. Seventeen children and adolescents with left- or right-sided ischemic stroke and 18 healthy controls were tested with a comprehensive neurolinguistic test battery, and the individual neural representation of language was measured with an fMRI language paradigm. Overall, 12 of 17 stroke patients showed language abilities below average, and five patients exhibited impaired language performance. fMRI revealed increased activity in right hemisphere areas homotopic to left hemisphere language regions. In sum, seven stroke patients revealed atypical, i.e. bilateral or right lateralized language representation. Typical left hemispheric language lateralization was associated with better performance in naming and word fluency, whereas increased involvement of right homologues was accompanied by worse language outcome. In contrast, lesion lateralization or lesion volume did not correlate with language outcome or atypical language lateralization. Thus, atypical language lateralization is unfavorable for language outcome, and right homologues do not have the same cognitive capacity, even in young children.

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Section: Discussionmentioning

confidence: 99%

Atypical language representation is unfavorable for language abilities following childhood stroke

Bartha‐Doering

Novak

Kollndorfer

et al. 2019

European Journal of Paediatric Neurology

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“…During fMRI assessment, the German version of an auditory description definition task was administered (Bartha‐Doering, Kollndorfer, et al, 2018; Bartha‐Doering, Novak, et al, 2018; Berl et al., 2014; Sepeta et al., 2016). In the auditory description definition condition, the participants heard the definition of an object followed by a noun and were instructed to press a button each time the definition truly described the noun.…”

Section: Methodsmentioning

confidence: 99%

“…Each block lasted for 40 s and consisted of 10 sentences presented every 4 s. Total fMRI scan time was 6 min 40 s. Task performance was evaluated by the overall accuracy in the language condition and the control task separately. Detailed description of the fMRI paradigm can be found in Bartha‐Doering, Kollndorfer, et al (2018), Bartha‐Doering, Novak, et al (2018), or Bartha‐Doering et al. (2019).…”

Section: Methodsmentioning

confidence: 99%

The role of the corpus callosum in language network connectivity in children

Bartha‐Doering

Kollndorfer

Schwartz

et al. 2020

Developmental Science

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The specific role of the corpus callosum (CC) in language network organization remains unclear, two contrasting models have been proposed: inhibition of homotopic areas allowing for independent functioning of the hemispheres versus integration of information from both hemispheres. This study aimed to add to this discussion with the first investigation of language network connectivity in combination with CC volume measures. In 38 healthy children aged 6–12, we performed task‐based functional magnetic resonance imaging to measure language network connectivity, used structural magnetic resonance imaging to quantify CC subsection volumes, and administered various language tests to examine language abilities. We found an increase in left intrahemispheric and bilateral language network connectivity and a decrease in right intrahemispheric connectivity associated with larger volumes of the posterior, mid‐posterior, and central subsections of the CC. Consistent with that, larger volumes of the posterior parts of the CC were significantly associated with better verbal fluency and vocabulary, the anterior CC volume was positively correlated with verbal span. Thus, children with larger volumes of CC subsections showed increased interhemispheric language network connectivity and were better in different language domains. This study presents the first evidence that the CC is directly linked to language network connectivity and underlines the excitatory role of the CC in the integration of information from both hemispheres.

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“…The network of the left IFG and the precuneus may be involved in the naive phonetic processing of Kanji (Williams et al, 2015 ). Further, bilateral frontal involvement with weak semantic language lateralization is associated with a higher vocabulary in healthy children (Bartha-Doering et al, 2018 ). The fronto-parietal top-down control network might support rapid adjustment of multiple processes of Kanji reading (Dosenbach et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between Resting-State Functional Connectivity and Reading in Two Writing Systems in Japanese Children With and Without Developmental Dyslexia

et al. 2020

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Introduction: Japanese is unique, as it features two distinct writing systems that share the same sound and meaning: syllabic Hiragana and logographic Kanji scripts. Acquired reading difficulties in Hiragana and Kanji have been examined in older patients with brain lesions. However, the precise mechanisms underlying deficits in developmental dyslexia (DD) remain unclear. Materials and Methods: The neural signatures of Japanese children with DD were examined by using restingstate functional magnetic resonance imaging. We examined 22 dyslexic and 46 typically developing (TD) children, aged 7-14 years. Results: Reading performance in each writing system was correlated with neural connectivity in TD children. In contrast, in children with DD, weak associations between neural connectivity and reading performance were observed. In TD children, Hiragana-reading fluency was positively correlated with the left fusiform gyrus network. No significant correlations between Hiragana fluency and neural connectivity were observed in children with DD. Correspondingly, there were fewer correlations between Kanji accuracy and strength of reading-related connectivity in children with DD, whereas positive correlations with the bilateral fronto-parietal network and negative correlations with the left fusiform network were found in TD children. Discussion: These data suggest that positive and negative coupling with neural connectivity is associated with developing Japanese reading skills. Further, different neural connectivity correlations between Hiragana fluency and Kanji accuracy were detected in TD children but less in children with DD. Conclusion: The two writing systems may exert differential effects and deficits on reading in healthy children and in children with DD, respectively.

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Weaker semantic language lateralization associated with better semantic language performance in healthy right‐handed children

Cited by 23 publications

References 87 publications

Atypical language representation is unfavorable for language abilities following childhood stroke

Atypical language representation is unfavorable for language abilities following childhood stroke

The role of the corpus callosum in language network connectivity in children

Association Between Resting-State Functional Connectivity and Reading in Two Writing Systems in Japanese Children With and Without Developmental Dyslexia

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