Weakness, SR function and stress in gastrocnemius muscles of aged male rats

Russ, David W.; Wills, Allison M.; Boyd, Iva M.; Krause, Jodi

doi:10.1016/j.exger.2013.11.018

Cited by 30 publications

(37 citation statements)

References 28 publications

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“…Classical ER stress can result from several by-products of reduced autophagy, including: unfolded proteins, glycation, perturbations in redox status or altered membrane lipids (Nikolova-Karakashian and Rozenova 2010), factors which could all affect the aging SR. Indeed, we reported that markers of sphingolipid, specifically ceramide, metabolism are elevated in the SR of aging gastrocnemius muscles (Russ et al 2014), supporting this latter mechanism. One might expect that increased ''SR stress'' would stimulate autophagy, in a classic feedback loop, but it has been suggested that aging compromises this adaptive response to stress (Naidoo 2009).…”

Section: Introductionsupporting

confidence: 61%

“…Because the SR of skeletal muscle is an abundant specialized form of ER (Volpe et al 1992), we speculate that there is an SR-specific autophagy in skeletal muscle, and that it is impaired with aging. In support of this concept, we have found increased markers of membrane damage and ER stress, in the SR of aging muscles (Russ et al 2012b(Russ et al , 2014. Classical ER stress can result from several by-products of reduced autophagy, including: unfolded proteins, glycation, perturbations in redox status or altered membrane lipids (Nikolova-Karakashian and Rozenova 2010), factors which could all affect the aging SR.…”

Section: Introductionmentioning

confidence: 52%

“…We have previously reported that aging rat gastrocnemius muscles exhibit a proportionately greater loss of force production than mass (i.e., a loss of muscle quality) (Russ et al , 2014, and reduced abundance of markers of basal autophagy (Russ et al 2012b), as have others (Wohlgemuth et al 2010). Thus, it is reasonable to consider impaired autophagy a potential contributing factor to age-related muscle weakness.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, it is reasonable to consider impaired autophagy a potential contributing factor to age-related muscle weakness. We have previously suggested that impaired autophagy in muscle may lead to deficits in sarcoplasmic reticulum (SR) function (Russ et al 2012b(Russ et al , 2014. Release of Ca 2?…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, several investigators have suggested that impairments of E-C coupling contribute to weakness in aging muscles, independent of changes in muscle size (Renganathan and Delbono 1998;Weisleder et al 2006), and our laboratory has found that SR-Ca 2? release is impaired in aging gastrocnemius muscles that also exhibit reduced muscle quality (Russ et al , 2014.…”

Section: Introductionmentioning

confidence: 99%

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Muscle-specificity of age-related changes in markers of autophagy and sphingolipid metabolism

et al. 2015

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Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments of muscle quality (force/unit muscle tissue) and autophagy and increased sarcoplasmic reticulum stress. The purpose of this study was to examine age-related changes in soleus muscle contractility and in markers of autophagy in the soleus and gastrocnemius muscles. We assessed in situ muscle force and size in the soleus muscle of adult (7-8 months) and aged (24-26 months) male, F344/BN rats. We used immunoblotting to compare abundance of markers of autophagy, sarcoplasmic reticulum (SR) stress and sphingolipid metabolism in the soleus and medial gastrocnemius (MG) muscles of these animals. Relative to adults, aged rats maintained soleus muscle quality and increased muscle size, resulting in increased tetanic force production. Immunoblotting revealed a general pattern of an age-related reduction of basal autophagy, despite increases in indicators of SR stress and upstream autophagic pathway activation in the MG. The MG also exhibited changes in markers of sphingolipid metabolism suggestive of increased muscle ceramide. Minimal age-related changes were observed in the soleus. The soleus maintains muscle mass and quality with age, and exhibits fewer age-related changes in markers of stress and autophagy than the MG. Based on these data, we suggest that maintenance of autophagy may preserve muscle quality by preventing excessive SR stress.

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Section: Introductionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Muscle-specificity of age-related changes in markers of autophagy and sphingolipid metabolism

et al. 2015

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Skeletal muscle performance and ageing

Tieland

Trouwborst

Clark

2017

J cachexia sarcopenia muscle

626

429

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The world population is ageing rapidly. As society ages, the incidence of physical limitations is dramatically increasing, which reduces the quality of life and increases healthcare expenditures. In western society, ~30% of the population over 55 years is confronted with moderate or severe physical limitations. These physical limitations increase the risk of falls, institutionalization, co‐morbidity, and premature death. An important cause of physical limitations is the age‐related loss of skeletal muscle mass, also referred to as sarcopenia. Emerging evidence, however, clearly shows that the decline in skeletal muscle mass is not the sole contributor to the decline in physical performance. For instance, the loss of muscle strength is also a strong contributor to reduced physical performance in the elderly. In addition, there is ample data to suggest that motor coordination, excitation–contraction coupling, skeletal integrity, and other factors related to the nervous, muscular, and skeletal systems are critically important for physical performance in the elderly. To better understand the loss of skeletal muscle performance with ageing, we aim to provide a broad overview on the underlying mechanisms associated with elderly skeletal muscle performance. We start with a system level discussion and continue with a discussion on the influence of lifestyle, biological, and psychosocial factors on elderly skeletal muscle performance. Developing a broad understanding of the many factors affecting elderly skeletal muscle performance has major implications for scientists, clinicians, and health professionals who are developing therapeutic interventions aiming to enhance muscle function and/or prevent mobility and physical limitations and, as such, support healthy ageing.

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