Weaning is an essential process to meet the nutritional demand of the growing infant.The aim of this study was to explore the weaning practices used by Jordanian mothers to wean their infants from breastfeeding. A qualitative exploratory approach was used in this study. Six focus group discussions were conducted in three maternal child health centres in Zarqa city, Jordan, with 35 participants, who were selected purposefully. Interviews were audiotaped and transcribed verbatim. Transcripts were analysed using the process of thematic analysis. Five major themes emerged; these included 'Reasons for weaning', 'Confusion and challenges experienced with weaning', 'Lack of instructions', 'Methods of weaning' and 'Psychological impact on mothers'. The study showed that weaning infants yielded a set of obstacles while shifting to solid foods. Guilt, fear of complications and lack of self-confidence were emotions that emerged during the weaning process. All mothers complained of a lack of health education regarding weaning of infants. Health education by healthcare providers about weaning practices utilising official weaning guidelines is a highly appreciated and validated approach to help mothers facing challenges associated with weaning.Choosing the appropriate time of weaning, food choices, determining the amount and consistency of food, and dealing with discomfort associated with weaning are issues that must be discussed with mothers by health professionals.