Wear behaviour of cross-linked polyethylene assessed in vitro under severe conditions

Affatato, Saverio; Bersaglia, G.; Rocchi, M.; Taddei, Paola; Fagnano, C.; Toni, Aldo

doi:10.1016/j.biomaterials.2004.07.070

Cited by 97 publications

(97 citation statements)

References 42 publications

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“…Other protocols have placed third body particles directly in the articulating surface (Davidson et al, 1994;McKellop et al, 1981;McKellop and Rostlund, 1990;McNie et al, 2000), or have indirectly simulated third body effects using abrasion-tumbling, emery abrasion, or discrete scratching of femoral heads (Affatato et al, 2005;Barbour et al, 2000;Endo et al, 2001;McKellop et al, 1999;Wang et al, 1998); many of these studies also demonstrated increased polyethylene wear resulting from third body effects.…”

Section: Introductionmentioning

confidence: 99%

Effects of episodic subluxation events on third body ingress and embedment in the THA bearing surface

Heiner

Baer

Pedersen

et al. 2008

Journal of Biomechanics

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In total joint arthroplasty, third body particle access to the articulating surfaces results in accelerated wear. Hip joint subluxation is an under-recognized means by which third body particles could potentially enter the otherwise closely conforming articular bearing space. The present study was designed to test the hypothesis that, other factors being equal, even occasional events of femoral head subluxation greatly increase the number of third body particles that enter the bearing space and become embedded in the acetabular liner, as compared to level walking cycles alone. Ten metal-onpolyethylene hip joint head-liner pairs were tested in a multi-axis joint motion simulator, with CoCrMo third body particles added to the synovial fluid analog. All component pairs were tested for two hours of level walking; half also were subjected to twenty intermittent subluxation events. The number and location of embedded particles on the acetabular liners were then determined. Subluxation dramatically increased the number of third body particles embedded in the acetabular liners, and it considerably increased the amount of scratch damage on the femoral heads. Since both third body particles and subluxation frequently occur in contemporary total hip arthroplasty, their potent synergy needs to be factored prominently into strategies to minimize wear.

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Section: Introductionmentioning

confidence: 99%

Effects of episodic subluxation events on third body ingress and embedment in the THA bearing surface

Heiner

Baer

Pedersen

et al. 2008

Journal of Biomechanics

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“…The tissue has a high synthetic activity 1 and may contribute to bone lysis, which was first described in 1977. 2 Wear particles 3,4 trigger the invasion of inflammatory cells into the interface tissue. Some cell populations of the interface tissue release matrix-degrading enzymes 5 and cytokines.…”

Section: Introductionmentioning

confidence: 99%

Interface membrane fibroblasts around aseptically loosened endoprostheses express MMP‐13

Wagner

Gollwitzer

Wernicke

et al. 2007

Journal Orthopaedic Research

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The objective of this article was to assess whether matrix metalloproteinase-13 (MMP-13) is produced by cells of the peri-implant interface tissues and to further characterize these cells. Tissue specimens were collected from the bone-prosthesis interface at the time of revision surgery of clinically loosened hip and knee arthroplasties (n ¼ 27). Synovial tissues from osteoarthritic patients and young patients with mild joint deformity were used as controls (n ¼ 6). Tissue samples were fixed in 4% PFA, decalcified with EDTA, and embedded in paraffin. Sections (4 mm) were stained with hematoxylin/eosin and for the osteoclastic marker enzyme tartrate resistant acid phosphatase. Monocytes/macrophages were characterized with a monoclonal antibody against CD68 and mRNAs encoding MMP-13 and a 1 collagen I (COL1A1) were detected by in situ hybridization. Cells expressing transcripts encoding MMP-13 were found in 70% of the interface tissues. These cells colocalized with a cell population expressing COL1A1 mRNA, and were fibroblastic in appearance. MMP-13 expressing cells were found in the close vicinity of osteoclasts and multinuclear giant cells. No signals for transcripts encoding MMP-13 were detected in multinuclear giant cells or in osteoclasts. Control tissues were negative for transcripts encoding MMP-13 mRNA. Fibroblasts of the interface from aseptically loosened endoprostheses selectively express MMP-13. By the expression and the release of MMP-13, these fibroblastic cells may contribute to the local degradation of the extracellular matrix and to bone resorption. ß

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“…1,2 However, excessive wear of the ultrahigh molecular weight polyethylene (UHMWPE) acetabular component is one of the main causes of bone resorption, implant loosening, and ultimate failure of hip joint replacements. 3,4 Variation in the articulation patterns between the femoral head and the acetabular cup greatly influence wear rates in simulator tests [5][6][7][8] and computer models. 9 Unidirectional motion promotes orientation of the long polyethylene chains and subsequent hardening, 8 while multidirectional motion promotes an environment of continually changing shear.…”

mentioning

confidence: 99%

The influence of wear paths produced by hip replacement patients during normal walking on wear rates

Bennett¹,

Humphreys²,

O’Brien³

et al. 2008

Journal Orthopaedic Research

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Variation in wear paths is known to greatly affect wear rates in vitro, with multidirectional paths producing much greater wear than unidirectional paths. This study investigated the relationship between multidirectional motion at the hip joint, as measured by aspect ratio, sliding distance, and wear rate for 164 hip replacements. Kinematic input from three-dimensional gait analysis was used to determine the wear paths. Activity cycles were determined for a subgroup of 100 patients using a pedometer study, and the relationship between annual sliding distance and wear rate was analyzed. Poor correlations were found between both aspect ratio and sliding distance and wear rate for the larger group and between annual sliding distance and wear rate for the subgroup. However, patients who experienced a wear rate <0.08 mm/year showed a strong positive correlation between the combination of sliding distance, activity levels, and aspect ratio and wear rate (adjusted r 2 ¼ 55.4%). This group may represent those patients who experience conditions that most closely match those that prevail in simulator and laboratory tests. Although the shape of wear paths, their sliding distance, and the number of articulation cycles at the hip joint affect wear rates in simulator studies, this relationship was not seen in this clinical study. Other factors such as lubrication, loading conditions and roughness of the femoral head may influence the wear rate. ß

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Wear behaviour of cross-linked polyethylene assessed in vitro under severe conditions

Cited by 97 publications

References 42 publications

Effects of episodic subluxation events on third body ingress and embedment in the THA bearing surface

Effects of episodic subluxation events on third body ingress and embedment in the THA bearing surface

Interface membrane fibroblasts around aseptically loosened endoprostheses express MMP‐13

The influence of wear paths produced by hip replacement patients during normal walking on wear rates

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