PurposeThe purpose of the paper is to predict the erosion rate of the components of centrifugal pump under certain operating condition to identify the maximum erosion area and to discuss the factors affecting them. This helps to optimize design and estimate service life.Design/methodology/approachIn the paper, the Eulerian–Lagrangian approach method coupled with the erosion model to investigate the mixed sand characteristics on erosion characteristics of centrifugal pump flow-through wall. The hydraulic performance and wear characteristics experiment of the pump is used to verify the accuracy of the numerical simulation.FindingsThe blade erosion area mainly occurs near the blade inlet and the trailing edge of the pressure surface, the main erosion area of the impeller back shroud is near the outlet of the flow passage and the main erosion area of the volute is near the tongue and the I section. With the change of the average diameter and density of sand particles, the average erosion rate on different flow-through walls is positively correlated with the average mass concentration to a certain extent. However, for different sand shape factors, there is little correlation between the average erosion rate and the average mass concentration. In addition, compared with other erosion areas, the increase of average sand particle diameter and density has the greatest impact on the total erosion rate of blade pressure surface, while the shape of sand particles has a greater impact on the total erosion rate of each flow-through wall of centrifugal pump.Originality/valueIn this work, according to the characteristics of the mixed distribution of different sand diameters in the Yellow River Basin, the erosion characteristics of centrifugal pumps used in the Yellow River Basin are studied. The numerical calculation method for predicting the wall erosion of centrifugal pump is established and compared with the experimental results. The results can provide reference for optimizing design and increasing service life.