C oating titanium alloy implants with titanium nitride (TiN) by the method of Powder ImmersionReaction Assisted Coating (PIRAC) produces a stable layer on their surface. We have examined the ability of the new TiN coating to undergo osseointegration. We implanted TiN-coated and uncoated Ti6Al4V alloy pins into the femora of six-month-old female Wistar rats.SEM after two months showed a bone collar around both TiN-coated and uncoated implants. Morphometrical analysis revealed no significant differences between the percentage of the implant-bone contact and the area and volume of the bone around TiN-coated compared with uncoated implants. Electron-probe microanalysis indicated the presence of calcium and phosphorus at the implant-bone interface. Mineralisation around the implants was also confirmed by labelling with oxytetracycline. Strong activity of alkaline phosphatase and weak activity of tartrate-resistant acid phosphatase were shown histochemically. Very few macrophages were detected by the non-specific esterase reaction at the site of implantation.Our findings indicate good biocompatibility and bone-bonding properties of the new PIRAC TiN coatings which are comparable to those of uncoated Ti6Al4V alloy implants. Because of their excellent bio-and mechanical compatibility, titanium (Ti) alloys and Ti6Al4V in particular are often used as materials for femoral stems in cementless total hip prostheses.1-3 The advantages of Ti6Al4V are its superior corrosion resistance, high fatigue strength and low elastic modulus which reduces stress shielding. [2][3][4][5] In regard to abrasive and adhesive wear, however, titanium and Ti6Al4V appear to be inferior to other surgical alloys. [5][6][7][8] If an orthopaedic device is subjected to relative sliding at the Ti6Al4V-metal or Ti6Al4V-polyethylene interface there is damage to the passivating surface oxide, with the generation of particulate metal and polyethylene debris and enhanced release of metal ions. [5][6][7][8][9][10][11] This wear debris is responsible for the commonly observed blackening of adjacent tissues and is accompanied by the mobilisation of macrophages leading to osteolysis and aseptic loosening of the implant. [11][12][13][14][15][16][17][18] Thus, the more widespread use of Ti and its alloys in orthopaedics, especially as articulating components of total joint replacements, depends on our ability to modify their surface chemistry and microstructure. Various surface modifications have been used for improving the wear and corrosion behaviour of Ti alloys. The most commonly used are ultrapassivation of titanium and implantation of nitrogen ions. 1,4,[18][19][20][21] The latter has become a standard procedure for Ti alloys but it cannot guarantee adequate resistance to wear of the critical components of total joint replacements or of long-term service because of the rapid thinning of the hardened layer, which is about 0.5 m thick. [21][22][23] A variety of ceramic coatings has been tested and used for improving the properties of the metal surface and enha...