“…The cause of loosening is considered to be multifactorial and has been analyzed using several approaches: viz., clinical research on demographic and physiologic variables ( 5 , 9, 38-44), preparation and cementing technique (8,40,(45)(46)(47)(48), prosthetic design, positioning, friction and wear (1,3,5,8,9,(38)(39)(40)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62); biological responses studied in human investigations (63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78)(79) and in animal experiments (80)(81)(82)…”