The aim of the study was to investigate two-and three-body wear of CAD/CAM blocks. Four composite resins, one hybrid ceramic and one feldspar ceramic block material were examined. Six specimens each were tested in a ball-on-disc wear device fitted with a zirconia ball (50 N load, 1.2 Hz, 50 k cycles) in water for two-body and in poppy seed slurry for three-body wear evaluation. Volume loss after each 10 k cycle was quantified using a digital CCD microscope. Statistical analysis: ANOVA and Tukey's multiple comparisons (α=0.05). Two-body wear for composite resin blocks was small, hybrid ceramic and ceramic blocks showed larger volume loss. Threebody wear was very low for all materials. All CAD/CAM block materials investigated displayed low wear compared to previous data for direct posterior composites carrying out the same wear test. The block materials are considered suitable for fabrication of single full crown restorations on premolar teeth.