In this paper, our purpose is to calculate photon-matter interaction parameters of Ni-based alloys, Inconel-617 and Incoloy-800HT, which are the main candidates for high-temperature applications such as spacecraft, gas turbines, nuclear reactors and rocket motors. The radiation attenuation parameters and buildup factors were obtained in a wide energy range by using Phy-X/PSD and EpiXS softwares to determine the radiation protection capabilities of the alloys. Fast neutron removal cross sections of the alloys were also calculated. It was observed that Inconel-617 has higher shielding ability than Incoloy-800HT. The shielding potentials of the alloys were compared with those of other shielding materials (ordinary concrete, hematite-serpenite, ilmenite-limonite, steelscrap, basalt-magnetite, steel-magnetite and ilmenite concretes) reported before, and it was concluded that Inconel-617 and Incoloy-800HT have more shielding ability than those.