Wear Properties of UHMWPE Oriented under Uniaxial Compression during the Molten State and at Lower Temperatures than the Melting Point

Ohta, Makoto; Hyon, Suong Hyu; Kang, Yu Bong; Oka, M.; Tsutsumi, Sadami; Murakami, Syozo; Kohjiya, Shinzo

doi:10.1299/jsmec.46.1297

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…7,8 Protein and more general biomolecule layers are largely influenced by the biomaterials' surface characteristics, such as surface topography, 1,2,9,10 surface chemistry, 7,11 and surface crystallinity, 12 but also surface anisotropy on the molecular and supramolecular scale. 13 Introducing molecular chain orientation in UHMWPE by uniaxial compression or stretching can enhance the wear resistance as compared to the unoriented UHMWPE in water 14 and in the dry state. 15 With bovine serum albumin as lubricant, however, the improvement of wear resistance diminishes.…”

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How the Surface Nanostructure of Polyethylene Affects Protein Assembly and Orientation

et al. 2011

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Protein adsorption plays a key role in the biological response to implants. We report how nanoscale topography, chemistry, crystallinity, and molecular chain anisotropy of ultrahigh molecular weight polyethylene (UHMWPE) surfaces affect the protein assembly and induce lateral orientational order. We applied ultraflat, melt drawn UHMWPE films to show that highly oriented nanocrystalline lamellae influence the conformation and aggregation into network structures of human plasma fibrinogen by atomic force microscopy with unprecedented clarity and molecular resolution. We observed a transition from random protein orientation at low concentrations to an assembly guided by the UHMWPE surface nanotopography at a close to full surface coverage on hydrophobic melt drawn UHMWPE. This assembly differs from the arrangement at a hydrophobic, on the nanoscale smooth UHMWPE reference. On plasma-modified, hydrophilic melt drawn UHMWPE surfaces that retained their original nanotopography, the influence of the nanoscale surface pattern on the protein adsorption is lost. A model based on protein-surface and protein-protein interactions is proposed. We suggest these nanostructured polymer films to be versatile model surfaces to provide unique information on protein interactions with nanoscale building blocks of implants, such as nanocrystalline UHMWPE lamellae. The current study contributes to the understanding of molecular processes at polymer biointerfaces and may support their future design and molecular scale tailoring.

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confidence: 99%

“…Introducing molecular chain orientation in UHMWPE by uniaxial compression or stretching can enhance the wear resistance as compared to the unoriented UHMWPE in water and in the dry state . With bovine serum albumin as lubricant, however, the improvement of wear resistance diminishes .…”

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confidence: 99%

How the Surface Nanostructure of Polyethylene Affects Protein Assembly and Orientation

et al. 2011

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New Application of Radiation Crosslinking

2011

Radiation Processing of Polymer Materials and Its Industrial Applications

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Single‐Molecule Tracking of Fibrinogen Dynamics on Nanostructured Poly(ethylene) Films

Kastantin

Keller

Schwartz

2012

Adv Funct Materials

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Using fibrinogen (Fg) protein as a probe molecule, mapping using accumulated probe trajectories (MAPT) is performed on nanostructured melt‐drawn high‐density poly(ethylene) (HDPE) films composed of well‐oriented crystalline patches separated by amorphous regions. The spatially grouped molecular trajectories allow for identification of regions with distinct surface properties (i.e., crystalline vs. amorphous) while simultaneously determining the characteristic dynamic protein behavior within those regions. In the presence of solution with a sufficiently high Fg concentration, discrete patches of a dense, ordered protein layer form (presumably on crystalline HDPE regions), leading to a dramatic rise in the surface residence time (by more than two orders of magnitude) of molecules incorporated into the film. Within this ordered Fg layer, individual molecules exhibit slow anisotropic lateral diffusion; the mobility is restricted by the nanostructure boundaries of the underlying HDPE. On HDPE films at low Fg surface coverage, or on films that have been rendered hydrophilic with Ar plasma, short surface residence times and fast, isotropic diffusion are observed. These results demonstrate the ability of spatially resolved single‐molecule tracking to provide mechanistic information about biomolecule‐surface interactions in a highly heterogeneous environment.

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Wear Properties of UHMWPE Oriented under Uniaxial Compression during the Molten State and at Lower Temperatures than the Melting Point

Cited by 4 publications

References 22 publications

How the Surface Nanostructure of Polyethylene Affects Protein Assembly and Orientation

How the Surface Nanostructure of Polyethylene Affects Protein Assembly and Orientation

New Application of Radiation Crosslinking

Single‐Molecule Tracking of Fibrinogen Dynamics on Nanostructured Poly(ethylene) Films

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