Wearable and Miniaturized Sensor Technologies for Personalized and Preventive Medicine

Tricoli, Antonio; Nasiri, Noushin; De, Sayan

doi:10.1002/adfm.201605271

Cited by 289 publications

(212 citation statements)

References 177 publications

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“…was studied. When the filter was kept in K 3 [Fe(CN) 6 ] solution for 15 s, incomplete impregnation and a wide dispersion in found skin AOA values were observed. Holding the filter in the solution for 10 minutes resulted in excessive swelling and loosening of the filter material, its instability to subsequent mechanical actions.…”

Section: Wetting Time Of the Membrane Materials (Filter)mentioning

confidence: 99%

Optimized Potentiometric Assay for Non‐invasive Investigation of Skin Antioxidant Activity

2018

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The paper presents a new variant of non‐invasive potentiometric method for determination of human skin antioxidant activity (AOA). The use of a porous cellulose acetate membrane as the carrier for reagent solution (potassium hexacyanoferrate (III)) is presented. The increase of reagent shelf life, improvement the reproducibility of the results (during the day Sr≤0.08, interday Sr≤0.13) in comparison with previously described variant is demonstrated. It was shown that the components of the skin hydrolipid mantle and pH do not affect the potentiometric signal. The values of skin AOA determined by the developed method lie in the range 20–4000 μM‐eq. Recovery is Raverage=99 %. The skin of healthy people was studied by the developed method. The obtained results indicate the prospects of using a new non‐invasive approach in the study of the oxidation‐reduction balance of human skin.

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Section: Wetting Time Of the Membrane Materials (Filter)mentioning

confidence: 99%

Optimized Potentiometric Assay for Non‐invasive Investigation of Skin Antioxidant Activity

2018

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“…This technology can be extended to create a localized ion map under the microfluidic lens, continuously monitor allergens, and test systemic diseases including kidney function. With over hundred unanalyzed biomarkers in tear fluid, the exploitation of quantitative analysis through the microfluidic contact lens technology has the potential to create new diagnosis and treatment options in personalized medicine …”

Section: Resultsmentioning

confidence: 99%

Microfluidic Contact Lenses

Jiang

Montelongo

Butt

et al. 2018

Small

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Contact lens is a ubiquitous technology used for vision correction and cosmetics. Sensing in contact lenses has emerged as a potential platform for minimally invasive point-of-care diagnostics. Here, a microlithography method is developed to fabricate microconcavities and microchannels in a hydrogel-based contact lens via a combination of laser patterning and embedded templating. Optical microlithography parameters influencing the formation of microconcavities including ablation power (4.3 W) and beam speed (50 mm s ) are optimized to control the microconcavity depth (100 µm) and diameter (1.5 mm). The fiber templating method allows the production of microchannels having a diameter range of 100-150 µm. Leak-proof microchannel and microconcavity connections in contact lenses are validated through flow testing of artificial tear containing fluorescent microbeads (Ø = 1-2 µm). The microconcavities of contact lenses are functionalized with multiplexed fluorophores (2 µL) to demonstrate optical excitation and emission capability within the visible spectrum. The fabricated microfluidic contact lenses may have applications in ophthalmic monitoring of metabolic disorders at point-of-care settings and controlled drug release for therapeutics.

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“…CGM data can also be combined with variables and signals collected by other wearable sensors, not specific for use in diabetes, like smart-watches [96,97] monitoring subject mobility, smart clothes measuring biometrics and activity [98,99] or miniaturized sensors for other biomarkers based on tears, saliva, sweat and breath analysis [100].…”

Section: Integration Of Cgm Data With Other Data Sources: Towards Bigmentioning

confidence: 99%

Wearable Continuous Glucose Monitoring Sensors: A Revolution in Diabetes Treatment

et al. 2017

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Worldwide, the number of people affected by diabetes is rapidly increasing due to aging populations and sedentary lifestyles, with the prospect of exceeding 500 million cases in 2030, resulting in one of the most challenging socio-health emergencies of the third millennium. Daily management of diabetes by patients relies on the capability of correctly measuring glucose concentration levels in the blood by using suitable sensors. In recent years, glucose monitoring has been revolutionized by the development of Continuous Glucose Monitoring (CGM) sensors, wearable non/minimally-invasive devices that measure glucose concentration by exploiting different physical principles, e.g., glucose-oxidase, fluorescence, or skin dielectric properties, and provide real-time measurements every 1-5 min. CGM opened new challenges in different disciplines, e.g., medicine, physics, electronics, chemistry, ergonomics, data/signal processing, and software development to mention but a few. This paper first makes an overview of wearable CGM sensor technologies, covering both commercial devices and research prototypes. Then, the role of CGM in the actual evolution of decision support systems for diabetes therapy is discussed. Finally, the paper presents new possible horizons for wearable CGM sensor applications and perspectives in terms of big data analytics for personalized and proactive medicine.

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Wearable and Miniaturized Sensor Technologies for Personalized and Preventive Medicine

Cited by 289 publications

References 177 publications

Optimized Potentiometric Assay for Non‐invasive Investigation of Skin Antioxidant Activity

Optimized Potentiometric Assay for Non‐invasive Investigation of Skin Antioxidant Activity

Microfluidic Contact Lenses

Wearable Continuous Glucose Monitoring Sensors: A Revolution in Diabetes Treatment

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