Wearable cardioverter defibrillator for preventing sudden cardiac death in patients at risk: An updated systematic review of comparative effectiveness and safety

Goetz, Gregor; Wernly, Bernhard; Wild, Claudia

doi:10.1016/j.ijcha.2023.101189

Cited by 4 publications

(3 citation statements)

References 56 publications

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“…The consequences of their judgement are as follows. Low compliance leads to lower effectiveness, therefore, we can expect an even greater effect associated to higher compliance, as indeed seen in real life studies as well as in the as-treated and per-protocol analyses of the RCT [7] , [8] , [9] . In terms of the adjudication committee, once a study participant has passed away, the focus of the adjudication committee is on the cause of death as the death itself is not in question.…”

mentioning

confidence: 76%

Critical appraisal of “Goetz G, Wernly B, Wild C (2023) Wearable cardioverter defibrillator for preventing sudden cardiac death in patients at risk: An updated systematic review of comparative effectiveness and safety. IJC Heart & Vasculature 45 (2023) 101189”. Comment to the authors reply

Semrau,

Nürnberg

2024

IJC Heart & Vasculature

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mentioning

confidence: 76%

Critical appraisal of “Goetz G, Wernly B, Wild C (2023) Wearable cardioverter defibrillator for preventing sudden cardiac death in patients at risk: An updated systematic review of comparative effectiveness and safety. IJC Heart & Vasculature 45 (2023) 101189”. Comment to the authors reply

Semrau,

Nürnberg

2024

IJC Heart & Vasculature

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“…The evidence to justify the expanding use in larger cohorts requires randomized controlled prospective trials as the data so far, apart from the VEST trial, is derived from observational studies and registries. This study design is influenced by the diversity of the reported patients and the lack of control groups [29].…”

Section: Discussionmentioning

confidence: 99%

Prevention of Early Sudden Cardiac Death after Myocardial Infarction Using the Wearable Cardioverter Defibrillator—Results from a Real-World Cohort

Rohrer,

Manninger,

Fiedler

et al. 2023

JCM

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Background: After acute myocardial infarction (AMI), patients are at risk of sudden cardiac death. The VEST trial failed to show a reduction in arrhythmic mortality in AMI patients with an LVEF ≤ 35% prescribed with a WCD, having a lower-than-expected WCD wearing compliance. Objectives: The aim was to investigate on outcomes of patients in a real-world Austrian cohort with good compliance. Methods: A retrospective analysis of all eligible Austrian WCD patients according to the VEST trial inclusion and exclusion criteria between 2010 and 2020 was performed. Results: In total, 105 Austrian patients (64 ± 11 years, 12% female; LVEF 28 ± 6%) received a WCD for a median of 69 (1; 277) days after AMI (wearing duration 23.5 (0; 24) hours/day). Within the first 90 days, 4/105 (3.8%) patients received 9 appropriate shocks (2 (1; 5) shocks). No inappropriate shocks were delivered, and 3/105 (2.9%) patients died during follow-up. Arrhythmic mortality (1.9% Austria vs. 1.6% VEST, p = 0.52), as well as all-cause mortality (2.9% vs. 3.1%, p = 0.42) was comparable in both cohorts. Conclusions: The WCD is a safe treatment option in a highly selected cohort of patients with LVEF ≤ 35% after AMI. However, despite excellent WCD wearing duration in our cohort, the arrhythmic mortality rate was not significantly different.

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“…It can be brought on by direct contact with allergens such as acrylic acid in self-adhesive electrodes, 10,11 propylene glycol in conductive gel, 12 or rubber and nickel in a TENS electrode. [13][14][15] Although the studies cited may have demonstrated limited skin irritation or dermatitis within the electrode boundaries, it is important to keep in mind that the electrical current has the potential to affect areas of the skin and other tissues that it passes through, which may lead to further adverse reactions.…”

mentioning

confidence: 99%

The effect of electrical stimulation on skin vulnerability to irritants

Almalty,

Hamed,

Jebril

et al. 2024

Skin Research and Technology

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PurposeElectrical stimulation (ES) is a widely used technique in the medical field for various purposes. The effect of ES on several skin properties has been investigated; however, its effect on skin vulnerability to irritants remains unknown. This study aimed to investigate the effects of ES application on skin vulnerability to external irritants.Materials and methodsAn experimental study on 12 healthy male subjects (Mean ± SD, 22.9 ± 3.6 years) who completed the study. The subjects were free of skin abnormalities in the volar aspect of both forearms. Three areas were allocated to each forearm and marked as areas 1, 2, and A in the treated forearm, and areas 3, 4, and B in the control forearm. ES was applied to the volar aspect of the treated forearm for 30 min three times a week, for 2 weeks. The effect of ES on skin vulnerability was investigated using 5% and 0.5% sodium lauryl sulfate (SLS) patches applied to both treated and control forearms. The skin response to irritants was evaluated using transepidermal water loss (TEWL) and a visual erythema score 24 h after patch removal.ResultsCompared to the control forearm, ES increased skin permeability and erythema in response to external irritants (SLS), as measured by the visual analog score (Z = 2.75, p = 0.006) and TEWL (p < 0.05), respectively.ConclusionsES escalates skin reactions to low concentrations of irritant substances, such as SLS, in the area between the two electrodes. This emphasizes the use of this substance, and similar irritants should be avoided in areas treated with ES.

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Wearable cardioverter defibrillator for preventing sudden cardiac death in patients at risk: An updated systematic review of comparative effectiveness and safety

Cited by 4 publications

References 56 publications

Critical appraisal of “Goetz G, Wernly B, Wild C (2023) Wearable cardioverter defibrillator for preventing sudden cardiac death in patients at risk: An updated systematic review of comparative effectiveness and safety. IJC Heart & Vasculature 45 (2023) 101189”. Comment to the authors reply

Critical appraisal of “Goetz G, Wernly B, Wild C (2023) Wearable cardioverter defibrillator for preventing sudden cardiac death in patients at risk: An updated systematic review of comparative effectiveness and safety. IJC Heart & Vasculature 45 (2023) 101189”. Comment to the authors reply

Prevention of Early Sudden Cardiac Death after Myocardial Infarction Using the Wearable Cardioverter Defibrillator—Results from a Real-World Cohort

The effect of electrical stimulation on skin vulnerability to irritants

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