In this work, a low-profile and flexible antenna operating in the ISM (2.4-2.4835) GHz band for bio-telemetry applications is presented. This antenna is designed on two flexible substrate materials: Roger RO3003 with a thickness of 0.254 mm and jeans fabric material with a thickness of 0.7 mm, of an overall foot print of 20 × 30 mm 2 . The deformation bending of the designed antenna in two different cases is studied. The designed antenna is backed by a 3 × 3 artificial magnetic conductor (AMC) array structure, which resulted in the final design configuration. The antenna is backed by an AMC array structure to achieve a lower specific absorption rate (SAR) as well as high gain when it is mounted on biological tissue. For validation, the antenna is fabricated on two flexible substrate materials and then measured in free space as well as on four different parts of the realistic human (chest, back, arm, and leg) body with and without AMC structure. Furthermore, the SAR is measured on cSAR3D flat. Finally, for reliable communication, the link margin is calculated.