Wearable dual-element intraocular pressure contact lens sensor

Karunaratne, I.K.; Lee, Ching Hymn Christopher; Or, Ping Wai; Wei, Yifan; Chong, Iok Tong; Yang, Yangfan; Yu, Minbin; Lam, David Chuen Chun

doi:10.1016/j.sna.2021.112580

Cited by 19 publications

(4 citation statements)

References 30 publications

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“…In the 1990s, Japanese scientists discovered multiwall carbon nanotubes [ 25 ]. This discovery has caused a worldwide upsurge of nanotechnology research.…”

Section: Related Workmentioning

confidence: 99%

Real-Time Monitoring of Intraocular Pressure in Glaucoma Patients Using Wearable Mobile Medicine Devices

Yuan

Zhang

2022

Journal of Healthcare Engineering

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Glaucoma is caused by excessive aqueous humor in the eye, resulting in a continuous or intermittent increase of intraocular pressure, which exceeds the tolerance of the eyeball and damages the optic nerve. Existing treatments for glaucoma do not work well or have significant side effects. Intraocular pressure signal is a very important physiological signal that needs real-time and accurate monitoring in glaucoma patients, especially in severe glaucoma patients. Therefore, long-term, real-time, and accurate monitoring of intraocular pressure is of great significance for the diagnosis and treatment of glaucoma patients. The use of wearable devices for real-time ocular diagnosis and treatment of glaucoma patients is an effective approach. However, the current commonly used intraocular pressure measurement and monitoring technology is difficult to meet the diagnosis and monitoring needs of glaucoma patients in terms of size, measurement accuracy, power consumption, and intelligence. Therefore, facing the needs of glaucoma disease treatment, this topic studies an implantable flexible intraocular pressure sensor for long-term continuous monitoring of intraocular pressure in glaucoma patients and mainly focuses on the working principle, structural design, process fabrication, measurement and control system, characterization, and performance test of the intraocular pressure sensor. It is of great significance for personalized and accurate treatment of glaucoma patients.

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“…In the 1990s, Japanese scientists discovered multiwall carbon nanotubes [ 25 ]. This discovery has caused a worldwide upsurge of nanotechnology research.…”

Section: Related Workmentioning

confidence: 99%

Real-Time Monitoring of Intraocular Pressure in Glaucoma Patients Using Wearable Mobile Medicine Devices

Yuan

Zhang

2022

Journal of Healthcare Engineering

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“…One such outcome is designing soft and comfortable contact lenses; thus, researchers have introduced new materials, such as room temperature liquid Galinstan to attain such an outcome [99]. Another desirable outcome has been to improve the sensitivity of the sensors and reduce the measurement error gag, where again, researchers have made substantial leaps forwards [100]. Such improvements over the years will surely drive commercialization and improvement in current approved IOP sensors, such as the ones described in later sections.…”

Section: Inductive Couple Telemetry Sensorsmentioning

confidence: 99%

Advancements in Wearable and Implantable Intraocular Pressure Biosensors for Ophthalmology: A Comprehensive Review

Wu,

Mina,

Carbonneau

et al. 2023

Micromachines

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Glaucoma, marked by its intricate association with intraocular pressure (IOP), stands as a predominant cause of non-reversible vision loss. In this review, the physiological relevance of IOP is detailed, alongside its potential pathological consequences. The review further delves into innovative engineering solutions for IOP monitoring, highlighting the latest advancements in wearable and implantable sensors and their potential in enhancing glaucoma management. These technological innovations are interwoven with clinical practice, underscoring their real-world applications, patient-centered strategies, and the prospects for future development in IOP control. By synthesizing theoretical concepts, technological innovations, and practical clinical insights, this review contributes a cohesive and comprehensive perspective on the IOP biosensor’s role in glaucoma, serving as a reference for ophthalmological researchers, clinicians, and professionals.

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“…Therefore, there is an ongoing drive to develop SCL biosensors for real-time, continuous, and accurate IOP detection. [155,156] A microfluidic strain sensor has been designed based on a camera-detectable transduction technique, for which the subtle strain changes could be converted into a fluidic volume expansion/contraction (Figure 4a). [157] This microfluidic strain sensor could achieve a 0.06% and 0.004% detection limit for uniaxial and biaxial strain, respectively, and the strain sensor was then integrated onto silicone CLs.…”

Section: Smart Contact Lens For Intraocular Pressure Monitoringmentioning

confidence: 99%

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Zhu

et al. 2022

Advanced Materials

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The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, we discussed the current status and potential of SCL development through This article is protected by copyright. All rights reserved. a comprehensive review from fabrication to applications to commercialization. First, we discuss the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications. Then, we review the latest advances in diagnostic and therapeutic SCLs for clinical translation. Later, we summarize the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices. We also provide an outlook, future opportunities, and challenges for developing next-generation SCL devices. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

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Wearable dual-element intraocular pressure contact lens sensor

Cited by 19 publications

References 30 publications

Real-Time Monitoring of Intraocular Pressure in Glaucoma Patients Using Wearable Mobile Medicine Devices

Real-Time Monitoring of Intraocular Pressure in Glaucoma Patients Using Wearable Mobile Medicine Devices

Advancements in Wearable and Implantable Intraocular Pressure Biosensors for Ophthalmology: A Comprehensive Review

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

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