Wearable multifunctional sweat-sensing system for efficient healthcare monitoring

Criscuolo, Francesca; Hanitra, Ivan Ny; Aiassa, Simone; Taurino, Irene; Oliva, Nicoló; Carrara, Sandro; Micheli, Giovanni De

doi:10.1016/j.snb.2020.129017

Cited by 59 publications

(43 citation statements)

References 38 publications

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“…Therefore, non-invasive therapeutic monitoring of lithium in sweat has been investigated. A microfabricated flexible electrochemical sensor made of a platinum potentiometric sensor with an electrochemically nanostructured solid-contact and a silver reference electrode (RE) has been designed as a wearable headband for remote monitoring of lithium levels in sweat ( Figure 4 b) [ 14 , 29 , 30 , 31 ]. Although sweat was reported to be suitable for non-invasive and decentralized monitoring of lithium, sweat-based TDM suffers from several issues such as possible presence of contamination and concerns regarding drug stability and concentration accuracy with sweat evaporation.…”

Section: Therapeutic Monitoring Of Lithium Levels In Different Biolog...mentioning

confidence: 99%

Advances in Therapeutic Monitoring of Lithium in the Management of Bipolar Disorder

Sheikh

Qassem

Triantis

et al. 2022

Sensors

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Since the mid-20th century, lithium continues to be prescribed as a first-line mood stabilizer for the management of bipolar disorder (BD). However, lithium has a very narrow therapeutic index, and it is crucial to carefully monitor lithium plasma levels as concentrations greater than 1.2 mmol/L are potentially toxic and can be fatal. The quantification of lithium in clinical laboratories is performed by atomic absorption spectrometry, flame emission photometry, or conventional ion-selective electrodes. All these techniques are cumbersome and require frequent blood tests with consequent discomfort which results in patients evading treatment. Furthermore, the current techniques for lithium monitoring require highly qualified personnel and expensive equipment; hence, it is crucial to develop low-cost and easy-to-use devices for decentralized monitoring of lithium. The current paper seeks to review the pertinent literature rigorously and critically with a focus on different lithium-monitoring techniques which could lead towards the development of automatic and point-of-care analytical devices for lithium determination.

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Section: Therapeutic Monitoring Of Lithium Levels In Different Biolog...mentioning

confidence: 99%

Advances in Therapeutic Monitoring of Lithium in the Management of Bipolar Disorder

Sheikh

Qassem

Triantis

et al. 2022

Sensors

View full text Add to dashboard Cite

show abstract

“…The sensors show linear responses in artificial sweat. Because of the good biocompatibility, flexibility and accurate sample handling this wearable framework is a significant step forward in the advancement of non-invasive tracking technologies for health, opening the way for better understanding of physiological parameters and clinical needs of individuals ( Criscuolo et al, 2021 ). Metals containing oxides, such as indium oxide and lead oxide, are more sensitive and can be used to make sensing electrodes for wearable electrochemical biosensors.…”

Section: Analytical Applications Of Conductive Nanomaterials In Electrochemical Biosensorsmentioning

confidence: 99%

Progress of Wearable and Flexible Electrochemical Biosensors With the Aid of Conductive Nanomaterials

Raza

Khokhar

et al. 2021

Front. Bioeng. Biotechnol.

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Conductive nanomaterials have recently gained a lot of interest due to their excellent physical, chemical, and electrical properties, as well as their numerous nanoscale morphologies, which enable them to be fabricated into a wide range of modern chemical and biological sensors. This study focuses mainly on current applications based on conductive nanostructured materials. They are the key elements in preparing wearable electrochemical Biosensors, including electrochemical immunosensors and DNA biosensors. Conductive nanomaterials such as carbon (Carbon Nanotubes, Graphene), metals and conductive polymers, which provide a large effective surface area, fast electron transfer rate and high electrical conductivity, are summarized in detail. Conductive polymer nanocomposites in combination with carbon and metal nanoparticles have also been addressed to increase sensor performance. In conclusion, a section on current challenges and opportunities in this growing field is forecasted at the end.

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“…Neither on-body tests nor tests simulating typical sweat flow rate (1.5 µL cm −2 min −1 )) were reported, so the response time of the sensor and the maximum operating time of the platform are unknown. This device has lately completed with more sensors and cotton has been used instead paper as microfluidic element [ 59 ].…”

Section: Paper-based Microfluidics For Wearable Devicesmentioning

confidence: 99%

Hybrid Technologies Combining Solid-State Sensors and Paper/Fabric Fluidics for Wearable Analytical Devices

2021

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The development of diagnostic tools for measuring a wide spectrum of target analytes, from biomarkers to other biochemical parameters in biological fluids, has experienced a significant growth in the last decades, with a good number of such tools entering the market. Recently, a clear focus has been put on miniaturized wearable devices, which offer powerful capabilities for real-time and continuous analysis of biofluids, mainly sweat, and can be used in athletics, consumer wellness, military, and healthcare applications. Sweat is an attractive biofluid in which different biomarkers could be noninvasively measured to provide rapid information about the physical state of an individual. Wearable devices reported so far often provide discrete (single) measurements of the target analytes, most of them in the form of a yes/no qualitative response. However, quantitative biomarker analysis over certain periods of time is highly demanded for many applications such as the practice of sports or the precise control of the patient status in hospital settings. For this, a feasible combination of fluidic elements and sensor architectures has been sought. In this regard, this paper shows a concise overview of analytical tools based on the use of capillary-driven fluidics taking place on paper or fabric devices integrated with solid-state sensors fabricated by thick film technologies. The main advantages and limitations of the current technologies are pointed out together with the progress towards the development of functional devices. Those approaches reported in the last decade are examined in detail.

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Wearable multifunctional sweat-sensing system for efficient healthcare monitoring

Cited by 59 publications

References 38 publications

Advances in Therapeutic Monitoring of Lithium in the Management of Bipolar Disorder

Advances in Therapeutic Monitoring of Lithium in the Management of Bipolar Disorder

Progress of Wearable and Flexible Electrochemical Biosensors With the Aid of Conductive Nanomaterials

Hybrid Technologies Combining Solid-State Sensors and Paper/Fabric Fluidics for Wearable Analytical Devices

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