Wearable optical resolution photoacoustic microscopy

Chen, Qian; Xie, Huikai; Xi, Lei

doi:10.1002/jbio.201900066

Cited by 41 publications

(39 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Revealing the activities of the brain is an important target for brain studies of small animal, which plays an essential role in basic studies of brain functional connectivity and disease . DRS‐PAM can be used for visualizing vascular dynamics of mouse's brain.…”

Section: Resultsmentioning

confidence: 99%

Wide‐field monitoring and real‐time local recording of microvascular networks on small animals with a dual‐raster‐scanned photoacoustic microscope

Yang

Wang

Zhang

et al. 2020

Journal of Biophotonics

View full text Add to dashboard Cite

Abstact Photoacoustic microscopy (PAM) provides a new method for the imaging of small‐animals with high‐contrast and deep‐penetration. However, the established PAM systems have suffered from a limited field‐of‐view or imaging speed, which are difficult to both monitor wide‐field activity of organ and record real‐time change of local tissue. Here, we reported a dual‐raster‐scanned photoacoustic microscope (DRS‐PAM) that integrates a two‐dimensional motorized translation stage for large field‐of‐view imaging and a two‐axis fast galvanometer scanner for real‐time imaging. The DRS‐PAM provides a flexible transition from wide‐field monitoring the vasculature of organs to real‐time imaging of local dynamics. To test the performance of DRS‐PAM, clear characterization of angiogenesis and functional detail was illustrated, hemodynamic activities of vasculature in cerebral cortex of a mouse were investigated. Furthermore, response of tumor to treatment were successfully monitored during treatment. The experimental results demonstrate the DRS‐PAM holds the great potential for biomedical research of basic biology.

show abstract

Section: Resultsmentioning

confidence: 99%

Wide‐field monitoring and real‐time local recording of microvascular networks on small animals with a dual‐raster‐scanned photoacoustic microscope

Yang

Wang

Zhang

et al. 2020

Journal of Biophotonics

View full text Add to dashboard Cite

show abstract

“…Among all the improvements, scanning protocol is the key of the strategy for PAM miniaturization. In this section, we will discuss handheld and semi-handheld PAM based on several novel scanning devices [ [100] , [101] , [102] , [103] , [104] , [105] , [106] , [107] , [108] , [109] , [110] , [111] , [112] , [113] , [114] , [115] ]. PAMs scanning with galvanometer scanners adopting two scanning mechanisms: raster scanning and rotatory scanning, have been discussed firstly.…”

Section: Progress In Handheld and Semi-handheld Pammentioning

confidence: 99%

“…In contrast, rotatory-scanning-based PAMs enables the development of semi-handheld PAMs with a large FOV, a high temporal resolution, elimination of relative motion between the imaging interface and the samples for both animal and human studies [ [103] , [104] , [105] ]. In addition to galvanometer, three types of MEMS scanner based on electrothermal [ [106] , [107] , [108] , [109] , [110] , [111] , [112] ], electrostatic [ 113 ] and electromagnetic [ 114 , [101] , [102] , [103] , [104] , [105] , [106] , [107] , [108] , [109] , [110] , [111] , [112] , [113] , [114] , [115] ] effects have been applied in the development of handheld PAMs with ultracompact designs.…”

Section: Progress In Handheld and Semi-handheld Pammentioning

confidence: 99%

Progress of clinical translation of handheld and semi-handheld photoacoustic imaging

Chen

Qin

et al. 2021

Photoacoustics

Self Cite

View full text Add to dashboard Cite

Photoacoustic imaging (PAI), featuring rich contrast, high spatial/temporal resolution and deep penetration, is one of the fastest-growing biomedical imaging technology over the last decade. To date, numbers of handheld and semi-handheld photoacoustic imaging devices have been reported with corresponding potential clinical applications. Here, we summarize emerged handheld and semi-handheld systems in terms of photoacoustic computed tomography (PACT), optoacoustic mesoscopy (OAMes), and photoacoustic microscopy (PAM). We will discuss each modality in three aspects: laser delivery, scanning protocol, and acoustic detection. Besides new technical developments, we also review the associated clinical studies, and the advantages/disadvantages of these new techniques. In the end, we propose the challenges and perspectives of miniaturized PAI in the future.

show abstract

“…Wearable optical resolution photoacoustic microscopy (W-ORPAM) is one of the wearable PAI system used for imaging the cerebral cortex in real time. 127 This technology exploits the variation in vasculature under different physiological conditions and was tested in mice. Another wearable device using PAI for monitoring the periodontal health was proved to be successful and this was confirmed in human.…”

Section: Conclusion and Future Scopementioning

confidence: 99%

Photoacoustic image-guided interventions

Karthikesh

Yang

2019

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Photoacoustic imaging has demonstrated its potential for diagnosis over the last few decades. In recent years, its unique imaging capabilities, such as detecting structural, functional and molecular information in deep regions with optical contrast and ultrasound resolution, have opened up many opportunities for photoacoustic imaging to be used during image-guided interventions. Numerous studies have investigated the capability of photoacoustic imaging to guide various interventions such as drug delivery, therapies, surgeries, and biopsies. These studies have demonstrated that photoacoustic imaging can guide these interventions effectively and non-invasively in real-time. In this minireview, we will elucidate the potential of photoacoustic imaging in guiding active and passive drug deliveries, photothermal therapy, and other surgeries and therapies using endogenous and exogenous contrast agents including organic, inorganic, and hybrid nanoparticles, as well as needle-based biopsy procedures. The advantages of photoacoustic imaging in guided interventions will be discussed. It will, therefore, show that photoacoustic imaging has great potential in real-time interventions due to its advantages over current imaging modalities like computed tomography, magnetic resonance imaging, and ultrasound imaging. Impact statement Photoacoustic imaging is an emerging modality for use in image-guided interventional procedures. This imaging technology has a unique ability to offer real-time, non-invasive, cost-effective, and radiation-free guidance in a real-world operating environment. This is substantiated in this article which sums up the current state and underlines promising results of research using photoacoustic imaging in guiding drug delivery, therapy, surgery, and biopsy. Hence, this minireview facilitates future research and real-world application of photoacoustic image-guided interventions.

show abstract

Wearable optical resolution photoacoustic microscopy

Cited by 41 publications

References 22 publications

Wide‐field monitoring and real‐time local recording of microvascular networks on small animals with a dual‐raster‐scanned photoacoustic microscope

Wide‐field monitoring and real‐time local recording of microvascular networks on small animals with a dual‐raster‐scanned photoacoustic microscope

Progress of clinical translation of handheld and semi-handheld photoacoustic imaging

Photoacoustic image-guided interventions

Contact Info

Product

Resources

About