Wearable patches for transdermal drug delivery

Enhancing Transdermal Delivery of Curcumin-Based Ionic Liquid Liposomes for Application in Psoriasis

“…Compared to other delivery methods, curcumin-based IL liposomes can self-compress and penetrate the pores between keratinocytes that are decimal times larger than themselves after deformation. They can efficiently permeate and diffuse into the skin and effectively deliver the required drug-active ingredients, − overcoming the related problems of traditional liposomes retaining the skin epidermal layer during transdermal administration (Figure a). At 24 h of percutaneous penetration, the cumulative penetration of Cur-Bet-IL-Lip was 49%, while Cur-Bet-IL was 36% (Figure b), indicating that IL liposomes can promote the penetration of curcumin.…”

Transdermal Patches Containing Opioids in the Treatment of Patients with Chronic Pain

“…Other types of transdermal patches based on the use of microneedles have also been proposed [37][38][39]. Such systems are used to administer drugs such as naltrexone [40], lidocaine [41], and insulin [42], but there are no papers involving the administration of opioids.…”

Novel SmartReservoirs for hydrogel-forming microneedles to improve the transdermal delivery of rifampicin

“…According to Fick's law, this leads to the diffusion of the drug contained within the SF into the skin layers, facilitating local deposition in the deep skin tissue or systemic absorption. 32,[46][47][48][49] Based on this, increasing the loading efficiency of solubilized rifampicin within the SF is expected to deliver greater amounts of the lipophilic antibiotic across the skin. This will ultimately improve upon the permeation profiles observed in previous studies which have investigated the transdermal delivery of rifampicin using MNs.…”