This systematic review focuses on control strategies and machine learning techniques used in prosthetic knees for restoring mobility of individuals with trans-femoral amputations. Review and classification of control strategies that determine how these prosthetic knees interact with the user and gait strategy inspired algorithms for phase identification, locomotion mode, and motion intention recognition were studied. Relevant studies were identified using electronic databases such as PubMed, EMBASE, SCOPUS, and the Cochrane Controlled Trials Register (Rehabilitation and Related Therapies) up to April 2021. Abstracts were screened and inclusion and exclusion criteria were applied. Out of 278 potentially relevant studies, 65 articles were included. The specific variables on control approach, control modes, gait control, hardware level, machine learning algorithm, and measured signals mechanism were extracted and added to summary table. The results indicate that advanced methods for adapting position or torque depiction and automatic detection of terrains or gait modes are more commonly utilized, but they are largely limited to laboratory environments. It is concluded that a correct combination of control strategies and machine learning techniques will enable the improvement of prosthetic performance and enhance the standard of amputee's lives.