Weaving for heart valve tissue engineering

Liberski, Albert Ryszard; Ayad, Nadia; Wojciechowska, Dorota; Kot, Radosław; Vo, Duy M. P.; Aibibu, Dilibaier; Hoffmann, G. W.; Cherif, Chokri; Grobelny-Mayer, Katharina; Snycerski, Marek; Goldmann, Helmut

doi:10.1016/j.biotechadv.2017.07.012

Cited by 25 publications

(29 citation statements)

References 70 publications

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“…Derwin et al reported using the woven poly-l-lactic acid (PLLA) X-Repair patch to provide bridging reinforcement for a shoulder tendon in a canine model. Post-operatively the augmented and repaired tendon was 23% significantly stronger, and after 12 weeks the patch reinforcement Woven designs showing plain, twill and satin weaves [10].…”

Section: Woven Tendon Bridging and Reinforcementmentioning

confidence: 95%

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Structural Design, Fabrication and Evaluation of Resorbable Fiber-Based Tissue Engineering Scaffolds

King¹,

Ji-yang²,

Deshpande³

et al. 2019

Biotechnology and Bioengineering

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The use of tissue engineering to regenerate viable tissue relies on selecting the appropriate cell line, developing a resorbable scaffold and optimizing the culture conditions including the use of biomolecular cues and sometimes mechanical stimulation. This review of the literature focuses on the required scaffold properties, including the polymer material, the structural design, the total porosity, pore size distribution, mechanical performance, physical integrity in multiphase structures as well as surface morphology, rate of resorption and biocompatibility. The chapter will explain the unique advantages of using textile technologies for tissue engineering scaffold fabrication, and will delineate the differences in design, fabrication and performance of woven, warp and weft knitted, braided, nonwoven and electrospun scaffolds. In addition, it will explain how different types of tissues can be regenerated by each textile technology for a particular clinical application. The use of different synthetic and natural resorbable polymer fibers will be discussed, as well as the need for specialized finishing techniques such as heat setting, cross linking, coating and impregnation, depending on the tissue engineering application.

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Section: Woven Tendon Bridging and Reinforcementmentioning

confidence: 95%

“…Compared with knitted and braided structures, woven fabrics have better mechanical strength and structural stability [9]. The properties of woven fabrics, such as thickness, porosity and strength, can be easily adjusted and modified by woven design selection and the density of the warp and weft yarns [10].…”

Section: Woven Scaffoldsmentioning

confidence: 99%

Structural Design, Fabrication and Evaluation of Resorbable Fiber-Based Tissue Engineering Scaffolds

King¹,

Ji-yang²,

Deshpande³

et al. 2019

Biotechnology and Bioengineering

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“…The concept was described in multiple scientific reports [2] and successes in the animal model were widely discussed [8][9][10]. Our added value was basing the scaffold manufacturing process on textile technology and using the advantages of the fabric architecture, which was discussed in depth elsewhere [4,7]. The problem.…”

Section: Rok a 34mentioning

confidence: 99%

“…He was associated with several local research institutions including WCM-Q, QCRC, Sidra Hospital, and QSTP. His work has been described in multiple scientific articles [2][3][4][5][6][7] and innovation disclosures (ID). His experiences in the development of in situ engineered heart valves may be presented in the context of the scientific and business relationship in Qatar.…”

Section: Insider Experience With Qatar Foundation Technology Transfermentioning

confidence: 99%

“…The corresponding author of this article is a member of the research team which focuses on developing a bioresorbable aortic heart valve (HV) prosthesis. During the last several years, a series of applicable solutions were proposed, some of which are summarized in the research articles [2][3][4][5][6][7]. Briefly, the solutions developed in the course of the research conducted in Qatar included fabrication of the smart scaffold (See Fig.…”

Section: Introductionmentioning

confidence: 99%

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Forming effective relationships between academia and the medical devices industry with a focus on launching a smart heart valve prosthesis for pediatric patients

et al. 2019

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Background: This article presents examples of how to utilize the research output, to initiate academia-industry interaction, with the ultimate task of launching a new product: a smart heart valve prosthesis for pediatric patients. The article summarizes our efforts in a way that may also be informative to researchers working in fields other than medical devices development. Our task is not to provide a step-by-step guide, but rather to create inspiration, also by describing differences in expectations of business and academic entities. Methods: We analyzed market reports, surveyed the scientific literature and conducted interviews with the key players in the field of medical devices. We also obtained a feedback from clinicians, academia and industry-related researchers, technology transfer centres, representatives of public organization and the creators of legislation. Results: We have obtained and reported the definitive answers that together constitute a critical review of strategies that should be used by researchers who seek to commercialize the outputs of their research. Conclusion: As a result of our investigation, we discovered that the commercialization of research is a complex process, which in some critical aspects does not depend solely on the researcher himself. The most promising ideas, supported by strong experimental evidence, can simply be overlooked by industry representatives, without the proper support of institutions such as a technology transfer centre. Besides, the involvement of scientists in a business project takes them, at least temporarily, outside the regular academic environment, which may cause discomfort and pose a risk to the career path. The limitation to be addressed is the reluctance to report the unsuccessful attempts, which should be considered a legitimate educational experience that ultimately leads to improvement.

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Protein‐Engineered Elastin Fibers as Building Blocks for The Textile‐Based Assembly of Tissue Equivalents

El Maachi,

Loewen,

Acosta

et al. 2024

Adv Funct Materials

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Native tissues feature unique hierarchical designs, in which fiber units are arranged from the bottom up in anisotropic patterns. The processing of biomaterials into fibers, followed by their textile‐like assembly into complex patterns, is therefore a promising avenue to engineer native‐like tissue replacements. Here it is shown for the first time the fabrication of meter‐long hydrogel fibers prepared from engineered elastin using a microinjection system and exploiting the catalyst‐free click chemistry. Given their similarity to native elastin, the fabricated elastin‐like fibers achieved excellent stretching (500%) and recoiling performance. Moreover, the fabrication scheme is compatible with the implementation of a salt‐leaching gas‐foaming approach, resulting in highly porous elastin‐like fibers (the first of their kind). From the translation perspective, the fibers can be autoclaved, which allows for sterilization and long‐term storage. Human umbilical vein endothelial cells cultured on autoclaved fibers produced a confluent endothelial layer lining the fiber surface, in which the cells became aligned in response to physiological fiber stretching. It is also shown that these functional fibers can be assembled by weaving, braiding and knitting, with various spatial patterns. Overall, the elastin‐like fibers can be used as building blocks for the reconstruction of functional tissues using the principles of textile technology.

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Weaving for heart valve tissue engineering

Cited by 25 publications

References 70 publications

Structural Design, Fabrication and Evaluation of Resorbable Fiber-Based Tissue Engineering Scaffolds

Structural Design, Fabrication and Evaluation of Resorbable Fiber-Based Tissue Engineering Scaffolds

Forming effective relationships between academia and the medical devices industry with a focus on launching a smart heart valve prosthesis for pediatric patients

Protein‐Engineered Elastin Fibers as Building Blocks for The Textile‐Based Assembly of Tissue Equivalents

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