Web-based trial to evaluate the efficacy and safety of tolterodine ER 4mg in participants with overactive bladder: REMOTE trial

National Randomized Controlled Trial of Virtual House Calls for People with Parkinson's Disease: Interest and Barriers

“…[57][58][59][60][61] The other principal source of delay was the requirement for hand-signed consent forms, which could be addressed by adopting the electronic signatures that are increasingly used in clinical trials. 38 Beyond this study, virtual house calls face additional policy barriers, especially licensure and reimbursement. Because state medical licensing boards generally require that a physician be licensed in the state where the patient is physically 74 some of which could be delivered remotely by other providers.…”

“…Other clinical studies that have used remote approaches to evaluate therapeutics have demonstrated the feasibility of such an approach. [38][39][40][41][42][43] That said, contacting many individuals was difficult because of telephone blocking services, absence of a prior relationship, and incomplete information provided. The inclusion of data checks to identify any missing responses would likely have reduced inadvertent omissions in sometimes lengthy forms and surveys.…”

Integration of advances in social media and mHealth technology are pivotal to successful cancer prevention and control

“…It has enhanced recruitment of patients and has been able overcome limitations of existing methods through which trials are run and patients are recruited (22,23). Caution is needed, however, when ultra-modern technologies are introduced in the setting of clinical trials to ensure key aspects such as consent are conducted in an appropriate manner (24). The Metastatic Breast Cancer Project recently reported that they have successfully recruited greater than 2,000 patients from every state in the US over a seven month period using social media and a dedicated website to recruit patients (25).…”

The Burden of a Remote Trial in a Nursing Home Setting: Qualitative Study (Preprint)

“…There is evidence that some clinical trials have leveraged digital technology to varying extents [16][17][18][19][20][21]. A study published in 2014 involving researchers from Pfizer, marked a clear departure from the traditional clinical model.…”

“…It sought to purposefully design and conduct a "virtual" trial. However, recruitment proved to be problematic and from 5,157 individuals who registered on the trial website only 18 were randomized to treat [18]. While the online informed consent process was successful, for those patients progressing to that stage, the lack of human interaction in the recruitment process was considered a major barrier, particularly in the population studies which comprised predominantly elderly subjects [22,23].…”