Establishment of alfalfa by interseeding into corn planted for silage can enhance crop productivity but weed management is a challenge to adoption. Although a glyphosate-based herbicide program could be a simple and effective approach, concerns about herbicide resistance and limitations in available alfalfa varieties exist. Field experiments were conducted to compare the efficacy and selectivity of preemergence (PRE), postemergence (POST) and PRE followed by POST herbicide programs to a glyphosate only strategy when interseeding alfalfa into corn. Experiment 1 compared PRE applications of acetochlor, mesotrione, S-metalochlor, metribuzin, and flumetsulam, and found both rates of acetochlor and metribuzin, and S-metalochlor at 1.1 kg ha-1 were the most effective and selective PRE herbicides 4 weeks after treatment (WAT), but each resulted in greater overall weed cover than glyphosate by 8 WAT. Experiment 2 evaluated POST applications at early and late timings of bentazon, bromoxynil, 2,4-DB, and mesotrione. Several POST herbicides exhibited similar effectiveness and selectivity as glyphosate including early applications of bromoxynil (0.14 kg ha-1) and 2,4-DB (0.84 or 1.68 kg ha-1), as well as late applications of bromoxynil (0.42 kg ha-1), 2,4-DB (0.84 kg ha-1) and mesotrione (0.05 or 0.11 kg ha-1). A third experiment compared applications of acetochlor PRE, bromoxynil POST, and the combination of acetochlor PRE with bromoxynil POST. All treatments were effective and safe for use in this interseeded system, although interseeded alfalfa provided 65-70% weed suppression in corn planted for silage without any herbicide. Herbicide treatments had no observable impacts on corn and alfalfa yields so weed management was likely of limited economic importance. However, weed competitiveness can vary based on several different factors including weed species, density, and site-specific factors, and so further investigations under different environments and conditions are needed.