Weekly Iron and Folic Acid Supplementation As a Tool to Reduce Anemia among Primary School Children in Cambodia

Longfils, Philippe; Heang, Ung Kim; Soeng, Hay; Muth, Sinuon

doi:10.1301/nr.2005.dec.s139-s145

Cited by 20 publications

(16 citation statements)

References 3 publications

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“…Southeast Asia is a region of the world with a major burden of IDA (Scrimshaw, 2004) and anemia is a major public health problem in Cambodia (Longfils et al, 2005), in particular during the first 2 years of life (HKI, 1999). Adequate nutrition is considered to be a basic human right Figure 3 Disease symptoms: listlessness, vomiting, diarrhea and acute respiratory infections (ARIs) were monitored by weekly questionnaires and during twice-weekly visits of trained village health workers.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of twice-weekly administration of three RDAs of iron and folic acid with and without complement of 14 essential micronutrients at one or two RDAs: a placebo-controlled intervention trial in anemic Cambodian infants 6 to 24 months of age

Schümann¹,

Longfils²,

Monchy

et al. 2007

Eur J Clin Nutr

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of twice-weekly administration of three RDAs of iron and folic acid with and without complement of 14 essential micronutrients at one or two RDAs: a placebo-controlled intervention trial in anemic Cambodian infants 6 to 24 months of age

Schümann¹,

Longfils²,

Monchy

et al. 2007

Eur J Clin Nutr

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“…For these reasons Honduras would benefit more from the implementation of a cost-effective preconceptional folic acid supplementation programme that would reach the poor urban and rural high-risk populations. Recently, the regional office of the WHO in South Asia (Philippines, Cambodia and Vietnam) published results on community trials assessing the effectiveness of micronutrient supplementation to the population with a pill containing both Fe and folic acid (37)(38)(39)(40)(41)(42) . The strategy tailored the supplementation intervention and market strategy to each country's culture and values.…”

Section: Discussionmentioning

confidence: 99%

Effect of different dosage and administration schedules of folic acid on blood folate levels in a population of Honduran women of reproductive age

Rosenthal

Milla²,

Flores

et al. 2008

Public Health Nutr.

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Background: Observational studies and clinical trials have shown conclusive evidence that periconceptional folic acid supplementation prevents up to 70 % of neural tube defects (NTD). The Honduran government wanted to implement a supplementation programme of folic acid but needed to assess the relative effects of two dosages of folic acid. Objective: To determine the effect of two dosages of folic acid on blood folate levels in Honduran female factory workers aged 18 to 49 years. Design: This was a randomized, double-blind control supplementation trial conducted in Choloma, Honduras. A total of 140 eligible women were randomly assigned to two dosage groups and followed up for 12 weeks. One group received a daily dosage of 1 mg folic acid and the other a once weekly dosage of 5 mg. Serum folate and red blood cell folate levels were determined by radioassay at baseline, 6 weeks and 12 weeks. Results: Serum folate levels increased from 6?3 (SE 0?2) to 14?9 (SE 0?6) ng/ml (P , 0?0001) in women assigned to the 1 mg/d group and from 6?9 (SE 0?3) to 10?1 (SE 0?4) ng/ml (P , 0?0001) in those assigned to the 5 mg/week group. Red blood cell folate concentrations also increased significantly in both groups, albeit more slowly. Educational level, age and BMI were not associated with the changes in serum and red blood cell folate levels during the supplementation period. However, a differential effect on serum folate levels by dosage group and time was observed. Conclusions: Although both folate supplementation regimens increased serum and red blood cell folate levels significantly among the women studied, blood folate levels that are considered to be protective of NTD were reached faster with the daily dosage of 1 mg folic acid.

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“…In a large-scale, 4-nation multicenter trial, the International Research on Infant Supplementation Study [12] , it was established that daily iron supplementation is more effective in a time-dependent manner than weekly dosing, but weekly dosing was significantly superior to placebo. In fact, weekly oral iron supplements reduced anemia in rural Cambodian schoolchildren [22] . Moreover, a systematic review of 55 trials suggests efficacy of iron supplementation for an iron-responsive change in hemoglobin among children under 6 years of age in nonmalarial areas on the order of 40-60% [23] .…”

Section: Iron In Pediatric Practicementioning

confidence: 95%

Efficacy and Safety of Iron Administration in Juvenile Populations

Schümann

Solomons²

2010

Ann Nestlé [Engl]

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Infantile iron deficiency anemia (IDA) reduces maximal lifetime cognitive capacity and can threaten the life of an adolescent mother in childbirth. Administration of iron is a component of strategies for preventing or reversing iron deficiency (ID) and iron can be given parenterally or as oral supplements or fortified food. Safety issues can arise at the point of administration, i.e. in the gut lumen, and as a consequence of excessive iron stores arising from the interventions. Recent improvements in the pharmacology of parenteral iron compounds open the way to greater consideration of the intravenous route in pediatric therapy, and even public health. Oral iron supplementation, usually with folic acid, is the main treatment of IDA in the clinical setting. It is often combined with multiple micronutrients and is also used for resolution of severe anemia at the community level and for prophylaxis in the nonanemic population. Fortification of staple food (such as flour), or age-specific foods (infant formula, complementary foods) and beverages are the usual methods for ID prophylaxis. Special iron-rich preparations (powders, crushable tablets, edible spreads) are available for home fortification. Biofortification, i.e. enriching the iron content of crops during cultivation, is a novel approach, yet to be fully implemented or evaluated for children. Side effects and toxicity after oral iron intake are seen in the gut lumen. After oral and parenteral iron intake, the rise in circulating iron can increase the risk of complications from coexisting infections, notably with malaria, and when individual iron status is adequate. Growth impairment occurs with exposure of iron-sufficient children to iron interventions, so that targeting of iron to ID individuals seems advisable. Numerous adverse consequences from accumulation of excessive total body iron stores show up as a consequence of iron-mediated oxidative stress. Incomplete maturation of iron homoeostasis may permit higher iron absorption before 6 months of age.

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Weekly Iron and Folic Acid Supplementation As a Tool to Reduce Anemia among Primary School Children in Cambodia

Cited by 20 publications

References 3 publications

Efficacy and safety of twice-weekly administration of three RDAs of iron and folic acid with and without complement of 14 essential micronutrients at one or two RDAs: a placebo-controlled intervention trial in anemic Cambodian infants 6 to 24 months of age

Efficacy and safety of twice-weekly administration of three RDAs of iron and folic acid with and without complement of 14 essential micronutrients at one or two RDAs: a placebo-controlled intervention trial in anemic Cambodian infants 6 to 24 months of age

Effect of different dosage and administration schedules of folic acid on blood folate levels in a population of Honduran women of reproductive age

Efficacy and Safety of Iron Administration in Juvenile Populations

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