Weekly Iron as a Safe Alternative to Daily Supplementation for Nonanemic Pregnant Women

Association between vitamin B12intake and EURRECA's prioritized biomarkers of vitamin B12in young populations: a systematic review

“…In that study, the selected biomarkers were measured at the age of 12 months. Mean (95 % CI) serum vitamin B 12 , HoloTC and MMA were 343 (319, 369) pmol/l, 54 (49,60) pmol/l and 0?22 (0?20, 0?25) mmol/l, respectively, for breast-fed infants, and 397 (372, 424) pmol/l, 76 (70,83) pmol/l and 0?20 (0?19, 0?22) mmol/l, respectively, for non-breast-fed infants. Infants who were breast-fed at the age of 12 months had significantly lower serum vitamin B 12 and HoloTC and higher MMA than those who were not breast-fed at the same age.…”

“…In that study, the dose-response association between injected vitamin B 12 and levels of biomarkers was not estimated. (58) Only data on biomarkers Monsen et al (2006) (59) Does not address any relationships of interest Casanueva et al (2006) (60) Type of intervention: multivitamin supplement Choudhry et al (1972) (61) Study design: intervention but not RCT Cikot et al (2001) (62) Only data on biomarkers Couto et al (2007) (63) Only data on biomarkers Cornel et al (2005) (64) Irrelevant micronutrient Czeizel and Dudas (1992) (65) Type of intervention: multi-vitamin supplement Czeizel and Medveczky (2003) (66) Does not address any relationships of interest Dagnelie et al (1989) (67) Does not address any relationships of interest Dawson et al (2000) (68) Study design: intervention but not RCT van Dusseldorp et al (1999) (69) Study design: case-control study Eilander et al (2010) (70) Study design: cross-sectional study investigating S-H relationship Gomber et al (2003) (71) Study design: cross-sectional study investigating S-H relationship Gomber et al (1998) (72) Study design: cross-sectional study investigating S-H relationship Gordon and Carson (1976) (73) Study design: case report Graham et al (1992) (74) Population group: infants did not meet the inclusion criteria (unhealthy) Haggarty et al (2006) (75) Irrelevant health outcome (76) Type of intervention: multi-vitamin supplement …”

Impact of twice weekly versus daily iron supplementation during pregnancy on maternal and fetal haematological indices: a randomized clinical trial

“…Interaction of iron with other micronutrients especially zinc, and also the postulated relationship between high-dose iron supplementation and pregnancy complications such as gestational diabetes, preterm labour and low birth weight, suggest that the amount of iron recommended in the current protocol is too high [3,[7][8][9][10]. A number of researchers propose that weekly iron supplementation is a reasonable alternative to daily supplementation in terms of haematological indices as well as side-effects [2,6,10,11].…”

“…Despite widespread preventive programmes, iron-deficiency anaemia during pregnancy is still prevalent and is associated with adverse pregnancy outcomes for both mother and newborn [1][2][3][4]. Poor client compliance with national iron supplementation protocols because of side-effects, especially gastrointestinal (GI) complications such as nausea, vomiting and constipation, is suggested as one of the main reasons for the inefficiency of these programmes [5].…”

Parenteral iron prophylaxis: a convenient alternative for antenatal women who do not consume oral iron

“…4 2015 Cochrane database suggests even intermittent oral iron prophylaxis can prevent anemia in pregnancy. 5,6 But many antenatal women are not able to consume iron by oral route even intermittently due to its well-known and common side effects. Many of them tend to discontinue the prescribed oral tablets due to adverse effects like nausea, vomiting, severe gastritis, gastro esophageal reflux, constipation and blackish discolouration of stools.…”