The Water-Energy-Food (WEF) Nexus has gained recognition as an innovative approach for analyzing the interconnectedness of global resource systems and achieving sustainability goals. In the Mediterranean, where water scarcity, climate change, and ecosystem degradation pose significant challenges, implementing an integrated Nexus approach is crucial. Through an integrative review of 136 scientific articles, we found that water-energy interlinkages dominate Nexus research in the Mediterranean, driven by the need for energy-intensive water distribution systems to meet drinking and irrigation water demands. However, the expansion of the Nexus approach to other components is limited, mostly focusing on assessing impacts on the physical environment and climate, without capturing feedback dynamics.

Furthermore, Nexus research in the Mediterranean is primarily conducted at isolated case study levels, with few studies working at the entire Mediterranean scale. There is promising evidence of Nexus research expanding to socio-economic interactions, cultural and behavioral change, and resource governance innovations, but these domains remain segregated due to limited integration of methods across disciplines. To advance Nexus implementation in the region, sustainable technology and natural resources management, which are key fields of operationalization, would benefit from harmonization.

In conclusion, Nexus research in the Mediterranean would benefit from integrating knowledge in multi-scale, multi-sector, and multi-dimensional frameworks to support technological, socio-economic, and governance interventions. This would enable a more comprehensive and coherent approach towards achieving water, food, and energy security while preserving the environment in the Mediterranean region.