Wegener Granulomatosis presenting with haemorragic stroke in a young adult

Granziera, Cristina; Michel, Patrik; Rossetti, Andrea O.; Lurati, Floriana; Reymond, Sitthided; Bogousslavsky, Julien

doi:10.1007/s00415-005-0702-6

Cited by 11 publications

(4 citation statements)

References 14 publications

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“…Although GPA can involve the central nervous system (), the risk of stroke associated with the syndrome is not well characterized. Ischemic and hemorrhagic strokes have been described in patients with GPA (), and some cases of stroke have been histologically linked to cerebral vasculitis (). To our knowledge, however, the incidence of stroke among GPA patients has not been examined in epidemiologic studies.…”

Section: Introductionmentioning

confidence: 99%

High Risk of Pulmonary Embolism and Deep Venous Thrombosis but Not of Stroke in Granulomatosis With Polyangiitis (Wegener's)

Faurschou

Obel

Baslund

2014

Arthritis Care & Research

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Section: Introductionmentioning

confidence: 99%

High Risk of Pulmonary Embolism and Deep Venous Thrombosis but Not of Stroke in Granulomatosis With Polyangiitis (Wegener's)

Faurschou

Obel

Baslund

2014

Arthritis Care & Research

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“…Mucosal hemorrhage in the lungs and gastrointestinal tract is frequent complication of small vessel vasculitides including WG, but much less common are intracerebral and intraventricular hemorrhage. ICH may occur as an initial manifestation or latter in the disease course despite being on standard immunosuppressive therapy as our patient [2,6]. This case also demonstrates that the development of CNS vasculitis may correlate with disease activity in other organs such as diffuse pulmonary hemorrhage.…”

Section: Discussionmentioning

confidence: 71%

Massive intracerebral hemorrhage associated with Wegener granulomatosis

Çeri¹,

Ortabozkoyun²,

Unverdi³

et al. 2011

Rheumatol Int

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Wegener granulomatosis (WG) is a necrotizing granulomatous vasculitis that predominantly affects airways and kidneys. But central nervous system involvement (7-11%) is an uncommon. Massive ICH may occur in the course of WG, and this serious condition is related with high risk of mortality. Therefore, the new treatment strategies may be considered in addition to classical practices in serious organ involvement and recurrent attack. Here, we present an adult patient with WG whose disease was complicated by a massive intracerebral hemorrhage (ICH), which subsequently led to death.

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“…For example, De Luna et al investigated 35 patients with GPA and CNS abnormalities and found that pachymeningitis (n=20) was more frequent than cerebral ischemic lesions (n=15) and ICH (n=2) ( 5 ). We searched the Medline database and found 24 cases of GPA-associated ICH (including the present case) ( 3 , 4 , 30 - 42 ). The male to female ratio was 3:1 and the average patient age was 45.1 years.…”

Section: Discussionmentioning

confidence: 99%

Granulomatosis with Polyangiitis Complicated by Hypertrophic Pachymeningitis Presenting with Simultaneous Multiple Intracerebral Hemorrhages

et al. 2018

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Central nervous system (CNS) involvement in granulomatosis with polyangiitis (GPA), including pachymeningitis and CNS vasculitis, is uncommon. Although intracerebral hemorrhage (ICH) has been reported in GPA, simultaneous multiple ICH (SMICH) is rare. We describe the case of a 50-year-old woman with a history of a limited form of GPA with chronic pachymeningitis who presented with acute-onset headache accompanied by nausea and vomiting, and who developed consciousness impairment. Computed tomography revealed bilateral subcortical ICH. Sinus thrombosis was not apparent on angiography. The patient was treated with high-dose corticosteroid therapy. The cause of the steroid-responsive SMICH in this case was unknown, but it might have been CNS vasculitis. Patients with GPA may present with SMICH, which is considered an indication for immunosuppressive therapy.

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Wegener Granulomatosis presenting with haemorragic stroke in a young adult

Cited by 11 publications

References 14 publications

High Risk of Pulmonary Embolism and Deep Venous Thrombosis but Not of Stroke in Granulomatosis With Polyangiitis (Wegener's)

High Risk of Pulmonary Embolism and Deep Venous Thrombosis but Not of Stroke in Granulomatosis With Polyangiitis (Wegener's)

Massive intracerebral hemorrhage associated with Wegener granulomatosis

Granulomatosis with Polyangiitis Complicated by Hypertrophic Pachymeningitis Presenting with Simultaneous Multiple Intracerebral Hemorrhages

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