Wegener's Granulomatosis

Walton, E. W.; Leggat, P.O.

doi:10.1136/jcp.9.1.31

Cited by 45 publications

(6 citation statements)

References 20 publications

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“…The prognosis for AAV has changed dramatically during the last 50 years, most notable for GPA. In the 1950s the mean survival of untreated WG was 5 months with less than 10% surviving 2 years [43]. After the introduction of cyclophosphamide and corticosteroids as standard treatment, patients now experience a one year survival of 93% and a 5 year and 10 year survival of 79% and 75% respectively [44].…”

Section: Resultsmentioning

confidence: 99%

A Case Series Study to Assess Body Mass Index in Patients’ with ANCA Associated Vasculitis

Akbar¹

2015

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Background: Vasculitis is an inflammatory process of the blood vessels, and is characterized histo-pathologically by inflammation and fibrinoid necrosis of the vessel wall. ANCA associated vasculitis follows a relapsing-remitting time course and accounts for considerable morbidity and mortality. The extensive renal injury that occurs often leads to end stage renal failure. The aim of this study was to investigate if body mass index has any relation to ANCA associated vasculitis, severity of disease presentation and if the distance from the biopsy center plays a role. Methods:We retrospectively reviewed charts of patients who had an international classification of diseases diagnosis of ANCA vasculitis and presented at Ruby Memorial Hospital-West Virginia University (Morgantown, West Virginia) between 2002 and 2013.Results: 11 patients (50%) were overweight while 16 patients (72.7%) had a body mass index greater than 25. Overall 13 patients (59%) were MPO positive. Of these, 9 patients (69.2%) were either overweight or obese, while of the patients with PR3 positivity, 7 patients (77.8%) were either overweight or obese. Out of the 22 patients who presented with AAV only 7 patients (31.8%) resided within a 10 mile radius of the biopsy center, while 15 patients (68.2%) resided more than 10 miles from the biopsy center of the 9 patients with greater than 50% crescents on their biopsy 4 needed renal replacement therapy and 4 needed therapeutic plasma exchange. Conclusion:Our results showed a predominantly overweight or obese population. Our results suggested a high prevalence of being either overweight or obesity in patients with PR3 as compared to MPO. Increased distance from the biopsy center did relate to an increased severity of disease at initial presentation. Further studies are required to determine if increased body mass index is a risk factor for the development of ANCA associated vasculitis.

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Section: Resultsmentioning

confidence: 99%

A Case Series Study to Assess Body Mass Index in Patients’ with ANCA Associated Vasculitis

Akbar¹

2015

NRT

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“…However, milder disease variants restricted to the respiratory tract (localised WG, locWG) have been reported to appear sporadically 7–12. In the American College of Rheumatology (ACR) classification criteria locWG is not considered,13 yet the Chapel Hill Consensus (CHC) definitions clearly state that ‘granulomatous variants’ can occur 14.…”

Section: Introductionmentioning

confidence: 99%

Prospective long-term follow-up of patients with localised Wegener's granulomatosis: does it occur as persistent disease stage?

et al. 2010

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“…In one GPA case, multiple small bowel ulcers and perforations were accompanied by spleen infarctions [ 9 ]. Walton and Leggat described a patient with anosmia, lung involvement, multiorgan failure, and spleen granulomas [ 15 ].…”

Section: Discussionmentioning

confidence: 99%