Wegener's granulomatosis

A Patient with Wegener’s Granulomatosis Presenting with a Subarachnoid Hemorrhage: Case Report and Review of CIMS Disease Associated with Wegener’s Granulomatosis

“…There have been several case reports of patients with WG that developed subarachnoid bleeding at some point during their course. In 2 cases SAH was diagnosed at autopsy [5,7], Two other patients carrying the diagnosis of WG developed evidence of subarachnoid bleeding later during their disease course [6]. To our knowledge, our patient is the first in whom the presenting problem was a SAH, after which the diagnosis of WG was made on renal biopsy.…”

“…There have been 7 previously documented patients with WG that either presented with or developed CNS complications [5][6][7][10][11][12] Four of the 7 patients developed a SAH. Two patients developed their SAH 3 and 36 months following the diag nosis of WG, and cerebral angiograms were negative in both cases [6], The other two SAHs were diagnosed at autopsy [5,7].…”

“…Two patients developed their SAH 3 and 36 months following the diag nosis of WG, and cerebral angiograms were negative in both cases [6], The other two SAHs were diagnosed at autopsy [5,7]. The last 3 patients presented with cerebral vasculitis, seizures, and a cerebrovascular accident, re spectively [10][11][12], CNS involvement in WG is caused primarily by three mechanisms: (l) Contiguous extension of granulomatous inflammation from primary sites outside the CNS.…”

“…How ever, the central nervous system is involved in less than 10% of the patients. There have only been 4 reported cases of subarachnoid hemorrhage (SAH) complicating WG [5][6][7], We now report the 1st patient with biopsyproven WG presenting with SAH. …”

Wegener’s Granulomatosis Presenting with Intracerebral Hemorrhages

“…Only a few cases of intracerebral or subarachnoid hemorrhage complicating Wegener's granulomatosis have been reported [2,[6][7][8][9]. Nervous system involvement, peripheral or central, is rare as initial presentation [4].…”