Wegener's granulomatosis and the heart.

Abstract

Three cases of Wegener's granulomatosis with cardiac complications are described and the relevant published reports are reviewed. The first case of Wegener's granulomatosis was associated with aortic regurgitation and required aortic valve replacement. The second and third cases were associated with pericardial disease requiring pericardiectomy for constructive pericarditis in one case, and haemorrhagic pericarditis with pericardial effusion in the other. Aortic valve involvement in Wegener's granulomatosis is uncommon and valve replacement has been described on only one previous occasion. Pericardial involvement is relatively common pathologically, but pericardial surgery has been described in this condition only twice, once for tamponade and once for constrictive pericarditis after pericardiocentesis. Cardiac involvement is not uncommon in patients with Wegner's granulomatosis and may be clinically important. Diagnosis is aided by estimation of the anti-neutophil cytoplasmic antibody titre.(Br Heart J 1994;71:82-86)

Wegener Granulomatosis: Case Report and Brief Literature Review

“…5,7,8,[11][12][13][14][15][16][17][18] Treatment Traditionally, initial therapy of WG consists of daily oral cyclophosphamide-corticosteroid combination therapy. This treatment has been quite effective in inducing remission in more than 90% of patients who adhere to this regimen; approximately 75% experience complete remission.…”

Cardiac manifestations in antineutrophil cytoplasmic autoantibody (ANCA) — associated vasculitides

“…It is usually asymptomatic, or may be manifested by chest pain or dyspnea [8][9][10]. Pericardial effusion can be due to the disease itself or due to uraemia in cases of renal failure [19,20].…”

“…Cardiac involvement in GPA occurs in 6% to 44% of cases [8,9] and is secondary to necrotising vasculitis with granulomatous infiltrates.…”

El Parmaklarinda Gangren Geli̇şen Bi̇r Vvegener Granülomatozu Olgusu (Bi̇r Wegener Granülomatozu Olgusu)

“…Değişik araştırmalarda kardiak tutulum%6-44 arasında değişmektedir. Kalp kası hastalığı, kalp blokları ve supraventriküler taşikar-diler, perikardial tamponant, aortik valvülit ve konstriktif perikardit bildirilen kalp bulguları arasındadır (9).…”