Wegener's granulomatosis presenting as facial palsy

Magliulo, Giuseppe; Varacalli, S; Sepe, C

doi:10.1016/s0196-0709(99)90049-2

Cited by 13 publications

(5 citation statements)

References 5 publications

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“…On the other hand, the dominant presenting symptoms of this entity include pulmonary infiltrates (71%), sinusitis (67%), and arthralgia (44%), 1 and facial palsy has also been reported. 3 In our patient the initial diagnosis was orbital complication of sinusitis. Ophthalmologic consultation revealed no visual loss and pseudotumor of the orbit was suspected.…”

Section: Discussionmentioning

confidence: 66%

“…The endoscopic sinus approach with biopsy is a very useful and cost-effective procedure along with serologic testing with ANCA; ANCA is associated with WG and has been found to be positive in 80% of cases. 3…”

Section: Discussionmentioning

confidence: 99%

“…An unfortunate case of WG mistaken for breast cancer with pseudotumor of the orbit was reported by Göbel et al 5 This misdiagnosis unfortunately resulted in enucleation and radical mastectomy because of misdiagnosed histopathologic specimens. The endoscopic sinus approach with biopsy is a very useful and cost‐effective procedure along with serologic testing with ANCA; ANCA is associated with WG and has been found to be positive in 80% of cases 3 …”

Section: Discussionmentioning

confidence: 99%

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Wegener's Granulomatosis Presenting in the Sinus and Orbit

Yücel

Keleş

Öztürk

et al. 2002

Otolaryngol.--head neck surg.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Wegener's Granulomatosis Presenting in the Sinus and Orbit

Yücel

Keleş

Öztürk

et al. 2002

Otolaryngol.--head neck surg.

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“…3 An otological involvement of Wegener's granulomatosis, as part of a generalized presentation, is quite a common clinical nding. 4 Nicklasson and Strangeland 5 reported that 38 per cent of the cases in their study exhibited such a condition. Occasionally, the ear is the only site of involvement.…”

Section: Introductionmentioning

confidence: 83%

“…This is similar to two of the previous reports in patients with SNHL and facial nerve palsy where middle-ear biopsies were reported as non-speci c granulations with no evidence of vasculitis. 4 ,7 Commonly used laboratory tests are not speci c for the disease, although an elevated erythrocyte sedimentation rate (ESR) is seen in 94 per cent 11 to 100 per cent 4,12 of cases. Anaemia may be present in 50 per cent to 70 per cent of cases.…”

Section: Discussionmentioning

confidence: 99%

Wegener’s granulomatosis: diagnostic dilemma

2001

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Wegener's granulomatosis is a systemic disease characterized by a granulomatous lesion that can affect any organ throughout the body. This case-report illustrates the problem posed by a patient presenting with bilateral serous otitis media with marked sensorineural hearing loss, facial nerve paralysis and an atypical serological picture. The importance of early diagnosis and the protocol for the management of a patient with an uncertain diagnosis is discussed. Due to atypical presentations, only a high index of suspicion will ensure an early diagnosis.

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Vasculitis of the central nervous system

Moore

2000

Curr Rheumatol Rep

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Central nervous system (CNS) vasculitis occurs in a variety of clinical settings. Some exhibit a distinct age preference; others a tissue tropism. Most frequently encountered are giant cell arteritis (temporal arteritis) and vasculitis secondary to infections. The CNS may be involved in the systemic vasculitides, and neurologic abnormalities occasionally appear as a presenting manifestation of disease. Isolated angiitis of the CNS, a rare form of vasculitis restricted to the CNS, must be distinguished from other causes of CNS inflammation and from noninflammatory vascular disease. We are learning a great deal about the cellular mechanisms of vascular inflammation in the brain. Some manifestations of the clinical disease result from histologic features of the infiltrate and the size of affected vessel. However, the local consequences of inflammation such as increased coagulation and altered vasomotor tone, as well as the systemic consequences such as activation of the central noradrenergic systems, trigeminovascular system, and hypothalamic pituitary adrenal axis contribute to both pathogenesis of disease and recovery. Two central issues that confront us now are improving the accuracy of the diagnosis (including identifying any underlying infectious causes) and limiting the long-term damage both from disease and its therapies.

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Wegener's granulomatosis presenting as facial palsy

Cited by 13 publications

References 5 publications

Wegener's Granulomatosis Presenting in the Sinus and Orbit

Wegener's Granulomatosis Presenting in the Sinus and Orbit

Wegener’s granulomatosis: diagnostic dilemma

Vasculitis of the central nervous system

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