Weighing in on heart failure: the potential impact of bariatric surgery

Datta, Tapan K; Lee, Andrew; Cain, Rachel; McCarey, Melissa; Whellan, David J.

doi:10.1007/s10741-021-10078-w

Cited by 10 publications

(4 citation statements)

References 38 publications

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“…The prevalence of obesity has increased drastically in recent years not only in adults but also in children, manifesting itself as a global health problem. Obesity has a considerable impact on metabolism, affecting the entire organism [ 1 ] and predisposing to comorbidities such as cancer [ 2 ], hypertension [ 3 ], insulin resistance and diabetes [ 4 ], neurological disorders [ 5 ] and cardiovascular diseases, including heart failure [ 1 ]. At the cardiac level, obesity exponentially increases the risk of heart failure development due to the impact of obesity on the heart [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Oxidative Stress Induces Cardiac Fibrosis in Obese Rats through Modulation of Transthyretin

Martínez‐Martínez

Fernández‐Irigoyen

Santamaría

et al. 2022

IJMS

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A proteomic approach was used to characterize potential mediators involved in the improvement in cardiac fibrosis observed with the administration of the mitochondrial antioxidant MitoQ in obese rats. Male Wistar rats were fed a standard diet (3.5% fat; CT) or a high-fat diet (35% fat; HFD) and treated with vehicle or MitoQ (200 μM) in drinking water for 7 weeks. Obesity modulated the expression of 33 proteins as compared with controls of the more than 1000 proteins identified. These include proteins related to endoplasmic reticulum (ER) stress and oxidative stress. Proteomic analyses revealed that HFD animals presented with an increase in cardiac transthyretin (TTR) protein levels, an effect that was prevented by MitoQ treatment in obese animals. This was confirmed by plasma levels, which were associated with those of cardiac levels of both binding immunoglobulin protein (BiP), a marker of ER stress, and fibrosis. TTR stimulated collagen I production and BiP in cardiac fibroblasts. This upregulation was prevented by the presence of MitoQ. In summary, the results suggest a role of TTR in cardiac fibrosis development associated with obesity and the beneficial effects of treatment with mitochondrial antioxidants.

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Section: Introductionmentioning

confidence: 99%

Mitochondrial Oxidative Stress Induces Cardiac Fibrosis in Obese Rats through Modulation of Transthyretin

Martínez‐Martínez

Fernández‐Irigoyen

Santamaría

et al. 2022

IJMS

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“… 2 , 6 , 16 In patients with obesity and altered ventricular function, surgical weight loss may result in ventricular reverse remodeling. 16 – 18 There are data to suggest that significant weight reduction reduces the left ventricular cavity size and improves cardiac hemodynamics, diastolic filling, NYHA functional class, and overall cardiac function. 2 , 6 , 18 …”

Section: Discussionmentioning

confidence: 99%

“… 16 – 18 There are data to suggest that significant weight reduction reduces the left ventricular cavity size and improves cardiac hemodynamics, diastolic filling, NYHA functional class, and overall cardiac function. 2 , 6 , 18 …”

Section: Discussionmentioning

confidence: 99%

Perioperative management of a patient with morbid obesity and severe cardiomyopathy: a case report and literature review

Xiang,

Liu,

et al. 2023

J Int Med Res

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As the obesity epidemic continues to escalate, the need for bariatric surgery will increase. Patients with severe cardiomyopathy and heart failure have historically been considered at high risk for perioperative complications and thus excluded from bariatric surgery. We herein describe a patient with morbid obesity, severe cardiomyopathy, and heart failure who successfully and safely underwent bariatric surgery and achieved significant weight loss and overall cardiac function improvement 1 year later. Although data are sparse, there is certainly evidence to suggest that significant weight reduction may confer a mechanism of ventricular reverse remodeling and subsequent clinical improvement.

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“…Among patients with NASH and obesity, bariatric surgery, compared with nonsurgical management, was also associated with a significantly lower risk of major adverse cardiovascular and liver-related outcomes [ 62 , 63 ]. Emerging evidence indicates that bariatric surgery might be also considered for treating severely obese patients with advanced HF [ 9 •], as this surgical procedure is able to improve cardiac structure and function [ 64 – 66 ].…”

Section: Pharmacological Treatments That Beneficially Affect Nafld An...mentioning

confidence: 99%

Non-Alcoholic Fatty Liver Disease as an Emerging Risk Factor for Heart Failure

Mantovani

Targher

2023

Curr Heart Fail Rep

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Purpose of the Review Non-alcoholic fatty liver disease (NAFLD) and heart failure (HF) are two chronic diseases that have become important global public health problems. This narrative review provides a comprehensive overview of the association between NAFLD and increased risk of new-onset HF, briefly discusses the putative biological mechanisms linking these two conditions, and summarizes targeted pharmacotherapies for NAFLD that might also beneficially affect cardiac complications leading to new-onset HF. Recent Findings Recent observational cohort studies supported a significant association between NAFLD and the long-term risk of new-onset HF. Notably, this risk remained statistically significant even after adjustment for age, sex, ethnicity, adiposity measures, pre-existing type 2 diabetes and other common cardiometabolic risk factors. In addition, the risk of incident HF was further increased with more advanced liver disease, especially with higher severity of liver fibrosis. There are multiple potential pathophysiological mechanisms by which NAFLD (especially in its more advanced forms) may increase the risk of new-onset HF. Summary Because of the strong link existing between NAFLD and HF, more careful surveillance of these patients will be needed. However, further prospective and mechanistic studies are required to better decipher the existing but complex link between NAFLD and risk of new-onset HF.

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Weighing in on heart failure: the potential impact of bariatric surgery

Cited by 10 publications

References 38 publications

Mitochondrial Oxidative Stress Induces Cardiac Fibrosis in Obese Rats through Modulation of Transthyretin

Mitochondrial Oxidative Stress Induces Cardiac Fibrosis in Obese Rats through Modulation of Transthyretin

Perioperative management of a patient with morbid obesity and severe cardiomyopathy: a case report and literature review

Non-Alcoholic Fatty Liver Disease as an Emerging Risk Factor for Heart Failure

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